Your browser doesn't support javascript.
loading
Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.
Kimura, Izumi; Yamasoba, Daichi; Nasser, Hesham; Ito, Hayato; Zahradnik, Jiri; Wu, Jiaqi; Fujita, Shigeru; Uriu, Keiya; Sasaki, Jiei; Tamura, Tomokazu; Suzuki, Rigel; Deguchi, Sayaka; Plianchaisuk, Arnon; Yoshimatsu, Kumiko; Kazuma, Yasuhiro; Mitoma, Shuya; Schreiber, Gideon; Asakura, Hiroyuki; Nagashima, Mami; Sadamasu, Kenji; Yoshimura, Kazuhisa; Takaori-Kondo, Akifumi; Ito, Jumpei; Shirakawa, Kotaro; Takayama, Kazuo; Irie, Takashi; Hashiguchi, Takao; Nakagawa, So; Fukuhara, Takasuke; Saito, Akatsuki; Ikeda, Terumasa; Sato, Kei.
Afiliación
  • Kimura I; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.
  • Yamasoba D; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.
  • Nasser H; Faculty of Medicine, Kobe University , Kobe, Japan.
  • Ito H; Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University , Kumamoto, Japan.
  • Zahradnik J; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University , Ismailia, Egypt.
  • Wu J; Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University , Sapporo, Japan.
  • Fujita S; Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel.
  • Uriu K; First Medical Faculty at Biocev, Charles University , Vestec-Prague, Czechia.
  • Sasaki J; Department of Molecular Life Science, Tokai University School of Medicine , Isehara, Japan.
  • Tamura T; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.
  • Suzuki R; Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Deguchi S; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.
  • Plianchaisuk A; Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
  • Yoshimatsu K; Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University , Kyoto, Japan.
  • Kazuma Y; Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University , Sapporo, Japan.
  • Mitoma S; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University , Sapporo, Japan.
  • Schreiber G; Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University , Sapporo, Japan.
  • Asakura H; Institute for Vaccine Research and Development (HU-IVReD), Hokkaido University , Sapporo, Japan.
  • Nagashima M; Center for iPS Cell Research and Application (CiRA), Kyoto University , Kyoto, Japan.
  • Sadamasu K; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.
  • Yoshimura K; Institute for Genetic Medicine, Hokkaido University , Sapporo, Japan.
  • Takaori-Kondo A; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University , Kyoto, Japan.
  • Ito J; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki , Miyazaki, Japan.
  • Shirakawa K; Department of Biomolecular Sciences, Weizmann Institute of Science , Rehovot, Israel.
  • Takayama K; Tokyo Metropolitan Institute of Public Health , Tokyo, Japan.
  • Irie T; Tokyo Metropolitan Institute of Public Health , Tokyo, Japan.
  • Hashiguchi T; Tokyo Metropolitan Institute of Public Health , Tokyo, Japan.
  • Nakagawa S; Tokyo Metropolitan Institute of Public Health , Tokyo, Japan.
  • Fukuhara T; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University , Kyoto, Japan.
  • Ikeda T; Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.
  • Sato K; International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.
J Virol ; 97(10): e0101123, 2023 10 31.
Article en En | MEDLINE | ID: mdl-37796123
ABSTRACT
IMPORTANCE Most studies investigating the characteristics of emerging SARS-CoV-2 variants have been focusing on mutations in the spike proteins that affect viral infectivity, fusogenicity, and pathogenicity. However, few studies have addressed how naturally occurring mutations in the non-spike regions of the SARS-CoV-2 genome impact virological properties. In this study, we proved that multiple SARS-CoV-2 Omicron BA.2 mutations, one in the spike protein and another downstream of the spike gene, orchestrally characterize this variant, shedding light on the importance of Omicron BA.2 mutations out of the spike protein.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genoma Viral / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / Mutación Límite: Humans Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Genoma Viral / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / Mutación Límite: Humans Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: Japón