Palbociclib sensitizes ER-positive breast cancer cells to fulvestrant by promoting the ubiquitin-mediated degradation of ER-&#945; via SNHG17/Hippo-YAP axis.

Lei, Lei; Huang, Yuan; Shi, Lei; Ye, Weiwu; Lv, Xianmei; Ying, Lisha; Yu, Xingfei; Cheng, Skye Hung-Chun; Zheng, Yabing

Palbociclib sensitizes ER-positive breast cancer cells to fulvestrant by promoting the ubiquitin-mediated degradation of ER-α via SNHG17/Hippo-YAP axis.

Lei, Lei; Huang, Yuan; Shi, Lei; Ye, Weiwu; Lv, Xianmei; Ying, Lisha; Yu, Xingfei; Cheng, Skye Hung-Chun; Zheng, Yabing.

Afiliación

Lei L; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Huang Y; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Shi L; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Ye W; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Lv X; Department of Radiation Oncology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang, China.
Ying L; Department of Breast Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Yu X; Zhejiang Cancer Institute, Zhejiang Cancer Hospital, Hangzhou, China.
Cheng SH; Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China.
Zheng Y; Department of Radiation Oncology, Koo Foundation, Sun Yat-Sen Cancer Center, Taipei, Taiwan.

Breast Cancer Res Treat ; 203(3): 613-625, 2024 Feb.

Article en En | MEDLINE | ID: mdl-37924380

Asunto(s)

Neoplasias de la Mama; Piperazinas; Piridinas; ARN Largo no Codificante; Animales; Humanos; Femenino; Neoplasias de la Mama/tratamiento farmacológico; Neoplasias de la Mama/genética; Neoplasias de la Mama/patología; Fulvestrant/farmacología; Fulvestrant/uso terapéutico; ARN Largo no Codificante/genética; Receptores de Estrógenos/metabolismo; Proteínas Serina-Treonina Quinasas; Ubiquitinas; Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos

Palabras clave

ER-positive breast cancer; ER-α; Fulvestrant resistance; LATS1; Palbociclib; SNHG17

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperazinas / Piridinas / Neoplasias de la Mama / ARN Largo no Codificante Límite: Animals / Female / Humans Idioma: En Revista: Breast Cancer Res Treat Año: 2024 Tipo del documento: Article País de afiliación: China

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