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Dectin-2 is critical for phagocyte function and resistance to Paracoccidioides brasiliensis in mice.
Cardoso-Miguel, Mariana de Resende Damas; Bürgel, Pedro Henrique; de Castro, Raffael Júnio Araújo; Marina, Clara Luna; de Oliveira, Stephan Alberto; Albuquerque, Patrícia; Silva-Pereira, Ildinete; Bocca, Anamélia Lorenzetti; Tavares, Aldo Henrique.
Afiliación
  • Cardoso-Miguel MRD; Graduate Program in Microbial Biology, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
  • Bürgel PH; Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
  • de Castro RJA; Graduate Program in Microbial Biology, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
  • Marina CL; Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
  • de Oliveira SA; Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
  • Albuquerque P; Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
  • Silva-Pereira I; Department of Cell Biology, Laboratory of Applied Immunology, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
  • Bocca AL; Graduate Program in Microbial Biology, Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, DF, Brazil.
  • Tavares AH; Department of Cell Biology, Laboratory of Molecular Biology of Pathogenic Fungi, University of Brasília, Brasília, DF, Brazil.
Med Mycol ; 61(11)2023 Nov 06.
Article en En | MEDLINE | ID: mdl-37960963
We report a critical role of the innate immune receptor Dectin-2 during Paracoccidioides brasiliensis infection. Fungal sensing by Dectin-2 improved the survival of mice and lowered fungal burden. Further, Dectin-2 was required for cytokine production, phagocytosis, and fungal killing by phagocytes.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Paracoccidioides / Paracoccidioidomicosis Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Paracoccidioides / Paracoccidioidomicosis Límite: Animals País/Región como asunto: America do sul / Brasil Idioma: En Revista: Med Mycol Asunto de la revista: MEDICINA VETERINARIA / MICROBIOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Brasil