Enhancing Selectivity of Protein Biopharmaceuticals in Ion Exchange Chromatography through Addition of Organic Modifiers.

Duivelshof, Bastiaan Laurens; Bouvarel, Thomas; Pirner, Sebastian; Larraillet, Vincent; Knaupp, Alexander; Koll, Hans; D'Atri, Valentina; Guillarme, Davy

Duivelshof, Bastiaan Laurens; Bouvarel, Thomas; Pirner, Sebastian; Larraillet, Vincent; Knaupp, Alexander; Koll, Hans; D'Atri, Valentina; Guillarme, Davy.

Afiliación

Duivelshof BL; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211 Geneva, Switzerland.
Bouvarel T; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU-Rue Michel Servet 1, 1211 Geneva, Switzerland.
Pirner S; School of Pharmaceutical Sciences, University of Geneva, CMU-Rue Michel Servet 1, 1211 Geneva, Switzerland.
Larraillet V; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, CMU-Rue Michel Servet 1, 1211 Geneva, Switzerland.
Knaupp A; Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
Koll H; Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
D'Atri V; Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.
Guillarme D; Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany.

Int J Mol Sci ; 24(23)2023 Nov 22.

Article en En | MEDLINE | ID: mdl-38068945

Asunto(s)

Productos Biológicos; Concentración de Iones de Hidrógeno; Anticuerpos Monoclonales/química; Solventes; Indicadores y Reactivos; Cromatografía por Intercambio Iónico/métodos

Palabras clave

Fab fragment; bispecific antibody; ion exchange chromatography; monoclonal antibody; organic modifier; salt gradient; salt-mediated pH gradient

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Productos Biológicos Idioma: En Revista: Int J Mol Sci Año: 2023 Tipo del documento: Article País de afiliación: Suiza

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