Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.

Blumenreich, Shani; Ben-Yashar, Doreen Padan; Shalit, Tali; Kupervaser, Meital; Milenkovic, Ivan; Joseph, Tammar; Futerman, Anthony H

Blumenreich, Shani; Ben-Yashar, Doreen Padan; Shalit, Tali; Kupervaser, Meital; Milenkovic, Ivan; Joseph, Tammar; Futerman, Anthony H.

Afiliación

Blumenreich S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Ben-Yashar DP; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Shalit T; The Mantoux Bioinformatics Institute and the Weizmann Institute of Science, Rehovot, Israel.
Kupervaser M; De Botton Protein Profiling Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.
Milenkovic I; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Joseph T; Department of Neurology, Medical University of Vienna, Vienna, Austria.
Futerman AH; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

J Neurochem ; 168(1): 52-65, 2024 01.

Article en En | MEDLINE | ID: mdl-38071490

Asunto(s)

Enfermedad de Gaucher; Animales; Ratones; Enfermedad de Gaucher/metabolismo; Proteómica; Glucosilceramidasa/genética; Encéfalo/metabolismo; Transglutaminasas/genética; Transglutaminasas/metabolismo

Palabras clave

Gaucher disease; RNAseq; glucosylceramide; pathogenesis; proteomics

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Gaucher Límite: Animals Idioma: En Revista: J Neurochem Año: 2024 Tipo del documento: Article País de afiliación: Israel

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