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Cell division cycle 42 effector protein 4 inhibits prostate cancer progression by suppressing ERK signaling pathway.
Zhang, Xiaowen; Yu, Tao; Gao, Guojun; Xu, Junbao; Lin, Ruihui; Pan, Zhifang; Liu, Jianying; Feng, Weiguo.
Afiliación
  • Zhang X; School of Life Science and Technology, Weifang Medical University, Weifang, China.
  • Yu T; Department of Nuclear Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan, China.
  • Gao G; Department of Urology Surgery, Affiliated Hospital of Weifang Medical University, Weifang, China.
  • Xu J; Cancer Center, Shandong Public Health Clinical Center, Shandong, China.
  • Lin R; School of Life Science and Technology, Weifang Medical University, Weifang, China.
  • Pan Z; School of Life Science and Technology, Weifang Medical University, Weifang, China.
  • Liu J; Department of Nuclear Medicine, The Third Affiliated Hospital of Shandong First Medical University, Jinan, China.
  • Feng W; School of Life Science and Technology, Weifang Medical University, Weifang, China.
Biomol Biomed ; 24(4): 840-847, 2023 Dec 27.
Article en En | MEDLINE | ID: mdl-38153517
ABSTRACT
Prostate cancer (PCa) is the most common malignancy among men worldwide. The cell division cycle 42 effector protein 4 (CDC42EP4) functions downstream of CDC42, yet its role and molecular mechanisms in PCa remain unexplored. This study aimed to elucidate the role of CDC42EP4 in the progression of PCa and its underlying mechanisms. Bioinformatical analysis indicated that CDC42EP4 expression was significantly lower in PCa tissue compared to normal prostate tissue. Cellular phenotyping analysis suggested that CDC42EP4 markedly inhibited the proliferation, migration, and invasion of PCa cells. Xenograft tumor assays further demonstrated that CDC42EP4 suppressed the growth of PCa cells in vivo. Mechanistically, the study established that CDC42EP4 inhibited the ERK pathway in PCa cells. Additionally, the ERK pathway inhibitor PD0325901 was employed, revealing that PD0325901 significantly nullified the effects of CDC42EP4 on PCa cell proliferation, migration, and invasion. Collectively, our findings demonstrate that CDC42EP4 acts as a critical tumor suppressor gene, inhibiting PCa cell proliferation, migration, and invasion through the ERK pathway, thereby presenting potential targets for PCa therapy.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Movimiento Celular / Sistema de Señalización de MAP Quinasas / Proliferación Celular Límite: Animals / Humans / Male Idioma: En Revista: Biomol Biomed Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Movimiento Celular / Sistema de Señalización de MAP Quinasas / Proliferación Celular Límite: Animals / Humans / Male Idioma: En Revista: Biomol Biomed Año: 2023 Tipo del documento: Article País de afiliación: China