Estimation of age of onset and progression of breast cancer by absolute risk dependent on polygenic risk score and other risk factors.
Cancer
; 130(9): 1590-1599, 2024 May 01.
Article
en En
| MEDLINE
| ID: mdl-38174903
ABSTRACT
BACKGROUND:
Genetic, lifestyle, reproductive, and anthropometric factors are associated with the risk of developing breast cancer. However, it is not yet known whether polygenic risk score (PRS) and absolute risk based on a combination of risk factors are associated with the risk of progression of breast cancer. This study aims to estimate the distribution of sojourn time (pre-clinical screen-detectable period) and mammographic sensitivity by absolute breast cancer risk derived from polygenic proï¬le and the other risk factors.METHODS:
The authors used data from a population-based case-control study. Six categories of 10-year absolute risk based on different combinations of risk factors were derived using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm. Women were classiï¬ed into low, medium, and high-risk groups. The authors constructed a continuous-time multistate model. To calculate the sojourn time, they simulated the trajectories of subjects through the disease states.RESULTS:
There was little diï¬erence in sojourn time with a large overlap in the 95% conï¬dence interval (CI) between the risk groups across the six risk categories and PRS studied. However, the age of entry into the screen-detectable state varied by risk category, with the mean age of entry of 53.4 years (95% CI, 52.2-54.1) and 57.0 years (95% CI, 55.1-57.7) in the high-risk and low-risk women, respectively.CONCLUSION:
In risk-stratiï¬ed breast screening, the age at the start of screening, but not necessarily the frequency of screening, should be tailored to a woman's risk level. The optimal risk-stratiï¬ed screening strategy that would improve the beneï¬t-to-harm balance and the cost-eï¬ectiveness of the screening programs needs to be studied.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Cancer
Año:
2024
Tipo del documento:
Article