Causal association between telomere length and colorectal polyps: A bidirectional two-sample Mendelian randomization study.
Medicine (Baltimore)
; 103(1): e36867, 2024 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-38181239
ABSTRACT
We performed a bidirectional 2-sample Mendelian randomization (MR) design to explore the causal relation between telomere length (TL) and colorectal polyps. Genome-wide association study summary data of TL and colorectal polyps were extracted from the IEU open genome-wide association study database. Single nucleotide polymorphisms were served as instrumental variables at the significance threshold of Pâ
<â
5â
×â
10-8. The inverse variance weighted method, MR-Egger method, and weight median method were performed for causal estimation in MR. Cochran Q test, MR-Egger intercept test, and leave-one-out analyses were performed to evaluate the pleiotropy of the MR results. One hundred and twenty-four single nucleotide polymorphisms were selected as instrumental variables. We found significant casual association between TL and colorectal polyps. Long TL increased the risk of colorectal polyps using the inverse variance weighted method [ukb-a-521 odds ratio (OR) 1.004, 95% confidence interval (CI) 1.001-1.007, Pâ
=â
.004; ukb-d-D12 OR 1.008, CI 1.004-1.012, Pâ
<â
.001; finn-b-CD2_BENIGN_COLORECANI_EXALLC2 OR 1.170, CI 1.027-1.332, Pâ
=â
.018]. Sensitivity analyses validated that the causality between TL and colorectal polyps was robust. The study provided a causal association between TL and colorectal polyps which indicated that TL might be served as a potential biomarker of colorectal polyps for screening and prevention. Nonetheless, the conclusions need further validation.
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1
Banco de datos:
MEDLINE
Asunto principal:
Pólipos del Colon
Tipo de estudio:
Clinical_trials
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2024
Tipo del documento:
Article
País de afiliación:
China