Rapid Development of Achalasia After SARS-CoV-2 Infection: Polymerase Chain Reaction Analysis of Esophageal Muscle Tissue.
Am J Gastroenterol
; 119(5): 987-990, 2024 05 01.
Article
en En
| MEDLINE
| ID: mdl-38265043
ABSTRACT
INTRODUCTION:
Achalasia has been linked to viruses. We have observed cases of rapid-developing achalasia post-coronavirus disease 2019 (COVID-19).METHODS:
We aimed to prospectively evaluate esophageal muscle for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from patients with rapid-onset achalasia post-COVID-19 and compare them with achalasia predating COVID-19 and achalasia with no COVID-19.RESULTS:
Compared with long-standing achalasia predating COVID-19 and long-standing achalasia with no COVID-19, the subjects with achalasia post-COVID-19 had significantly higher levels of messenger RNA for the SARS-CoV-2 nucleocapsid (N) protein, which correlated with a significant increase in the inflammatory markers NOD-like receptor family pyrin domain-containing 3 and tumor necrosis factor.DISCUSSION:
SARS-CoV-2, the virus responsible for COVID-19, is a possible trigger for achalasia.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Acalasia del Esófago
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SARS-CoV-2
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COVID-19
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Am J Gastroenterol
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos