Flavin-N5OOH Functions as both a Powerful Nucleophile and a Base in the Superfamily of Flavoenzymes.

Zhang, Qiaoyu; Chen, Qianqian; Shaik, Sason; Wang, Binju

Zhang, Qiaoyu; Chen, Qianqian; Shaik, Sason; Wang, Binju.

Afiliación

Zhang Q; State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
Chen Q; State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
Shaik S; Institute of Chemistry and the Lise Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel.
Wang B; State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.

Angew Chem Int Ed Engl ; 63(14): e202318629, 2024 04 02.

Article en En | MEDLINE | ID: mdl-38299700

Asunto(s)

Flavinas; Oxigenasas de Función Mixta; Flavinas/metabolismo; Oxigenasas de Función Mixta/metabolismo; Oxidación-Reducción; Oxidorreductasas; Compuestos Orgánicos

Palabras clave

Enzyme mechanisms; Flavin cofactors; Flavoenzymes; Oxygen activation; QM/MM calculations

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Flavinas / Oxigenasas de Función Mixta Idioma: En Revista: Angew Chem Int Ed Engl Año: 2024 Tipo del documento: Article

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