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Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment.
França, Lucas G S; Ciarrusta, Judit; Gale-Grant, Oliver; Fenn-Moltu, Sunniva; Fitzgibbon, Sean; Chew, Andrew; Falconer, Shona; Dimitrova, Ralica; Cordero-Grande, Lucilio; Price, Anthony N; Hughes, Emer; O'Muircheartaigh, Jonathan; Duff, Eugene; Tuulari, Jetro J; Deco, Gustavo; Counsell, Serena J; Hajnal, Joseph V; Nosarti, Chiara; Arichi, Tomoki; Edwards, A David; McAlonan, Grainne; Batalle, Dafnis.
Afiliación
  • França LGS; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
  • Ciarrusta J; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Gale-Grant O; Department of Computer and Information Sciences, Faculty of Engineering and Environment, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.
  • Fenn-Moltu S; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
  • Fitzgibbon S; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Chew A; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
  • Falconer S; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Dimitrova R; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
  • Cordero-Grande L; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Price AN; Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, OX3 9DU, UK.
  • Hughes E; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • O'Muircheartaigh J; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Duff E; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
  • Tuulari JJ; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Deco G; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Counsell SJ; Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid, 28040, Madrid, Spain.
  • Hajnal JV; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029, Madrid, Spain.
  • Nosarti C; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Arichi T; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Edwards AD; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
  • McAlonan G; Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Batalle D; MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
Nat Commun ; 15(1): 16, 2024 02 08.
Article en En | MEDLINE | ID: mdl-38331941
ABSTRACT
Brain dynamic functional connectivity characterises transient connections between brain regions. Features of brain dynamics have been linked to emotion and cognition in adult individuals, and atypical patterns have been associated with neurodevelopmental conditions such as autism. Although reliable functional brain networks have been consistently identified in neonates, little is known about the early development of dynamic functional connectivity. In this study we characterise dynamic functional connectivity with functional magnetic resonance imaging (fMRI) in the first few weeks of postnatal life in term-born (n = 324) and preterm-born (n = 66) individuals. We show that a dynamic landscape of brain connectivity is already established by the time of birth in the human brain, characterised by six transient states of neonatal functional connectivity with changing dynamics through the neonatal period. The pattern of dynamic connectivity is atypical in preterm-born infants, and associated with atypical social, sensory, and repetitive behaviours measured by the Quantitative Checklist for Autism in Toddlers (Q-CHAT) scores at 18 months of age.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Autístico / Recien Nacido Prematuro Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Child, preschool / Humans / Infant / Newborn Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Autístico / Recien Nacido Prematuro Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Child, preschool / Humans / Infant / Newborn Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article