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Brain artery diameters and risk of dementia and stroke.
Melgarejo, Jesus D; Gurel, Kursat; Compton, Cassidy Rose; Liu, Minghua; Guzman, Vanessa; Assuras, Stephanie; Levin, Bonnie E; Elkind, Mitchell S V; Ikram, M Kamran; Kavousi, Maryam; Ikram, M Arfan; Wright, Clinton; Crivello, Fabrice; Laurent, Alexandre; Tzourio, Christophe; Vernooij, Meike W; Rundek, Tatjana; Zhang, Zhen-Yu; Bos, Daniel; Gutierrez, Jose.
Afiliación
  • Melgarejo JD; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
  • Gurel K; Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
  • Compton CR; Institute of Neuroscience, University of Texas Rio Grande Valley, Harlingen, Texas, USA.
  • Liu M; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Guzman V; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Assuras S; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Levin BE; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Elkind MSV; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Ikram MK; Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
  • Kavousi M; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
  • Ikram MA; Department of Epidemiology, Mailman School of Public Health Columbia University, New York, New York, USA.
  • Wright C; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
  • Crivello F; Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
  • Laurent A; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
  • Tzourio C; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
  • Vernooij MW; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
  • Rundek T; Institute of Neurodegenerative Diseases, UMR5293, Neurofunctional Imaging Group, Bordeaux, France.
  • Zhang ZY; Institute of Neurodegenerative Diseases, UMR5293, Neurofunctional Imaging Group, Bordeaux, France.
  • Bos D; Bordeaux Population Health Research Center, Inserm, University Bordeaux, Bordeaux, France.
  • Gutierrez J; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Alzheimers Dement ; 20(4): 2497-2507, 2024 04.
Article en En | MEDLINE | ID: mdl-38332543
ABSTRACT

INTRODUCTION:

We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.

METHODS:

We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.

RESULT:

Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile.

DISCUSSION:

Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Demencia Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Accidente Cerebrovascular / Demencia Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Alzheimers Dement Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos