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A conserved interdomain microbial network underpins cadaver decomposition despite environmental variables.
Burcham, Zachary M; Belk, Aeriel D; McGivern, Bridget B; Bouslimani, Amina; Ghadermazi, Parsa; Martino, Cameron; Shenhav, Liat; Zhang, Anru R; Shi, Pixu; Emmons, Alexandra; Deel, Heather L; Xu, Zhenjiang Zech; Nieciecki, Victoria; Zhu, Qiyun; Shaffer, Michael; Panitchpakdi, Morgan; Weldon, Kelly C; Cantrell, Kalen; Ben-Hur, Asa; Reed, Sasha C; Humphry, Greg C; Ackermann, Gail; McDonald, Daniel; Chan, Siu Hung Joshua; Connor, Melissa; Boyd, Derek; Smith, Jake; Watson, Jenna M S; Vidoli, Giovanna; Steadman, Dawnie; Lynne, Aaron M; Bucheli, Sibyl; Dorrestein, Pieter C; Wrighton, Kelly C; Carter, David O; Knight, Rob; Metcalf, Jessica L.
Afiliación
  • Burcham ZM; Department of Animal Sciences, Colorado State University, Fort Collins, CO, USA.
  • Belk AD; Department of Microbiology, University of Tennessee, Knoxville, TN, USA.
  • McGivern BB; Department of Animal Sciences, Colorado State University, Fort Collins, CO, USA.
  • Bouslimani A; Department of Animal Sciences, Auburn University, Auburn, AL, USA.
  • Ghadermazi P; Department of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.
  • Martino C; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
  • Shenhav L; Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, USA.
  • Zhang AR; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
  • Shi P; Center for Studies in Physics and Biology, Rockefeller University, New York, NY, USA.
  • Emmons A; Institute for Systems Genetics, New York Grossman School of Medicine, New York University, New York, NY, USA.
  • Deel HL; Department of Computer Science, New York University, New York, NY, USA.
  • Xu ZZ; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
  • Nieciecki V; Department of Computer Science, Duke University, Durham, NC, USA.
  • Zhu Q; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
  • Shaffer M; Department of Animal Sciences, Colorado State University, Fort Collins, CO, USA.
  • Panitchpakdi M; Graduate Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO, USA.
  • Weldon KC; School of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
  • Cantrell K; Department of Animal Sciences, Colorado State University, Fort Collins, CO, USA.
  • Ben-Hur A; Graduate Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO, USA.
  • Reed SC; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
  • Humphry GC; School of Life Sciences, Arizona State University, Tempe, AZ, USA.
  • Ackermann G; Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, USA.
  • McDonald D; Department of Soil and Crop Sciences, Colorado State University, Fort Collins, CO, USA.
  • Chan SHJ; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
  • Connor M; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
  • Boyd D; Department of Computer Science and Engineering, University of California San Diego, La Jolla, CA, USA.
  • Smith J; Department of Computer Science, Colorado State University, Fort Collins, CO, USA.
  • Watson JMS; U.S. Geological Survey, Southwest Biological Science Center, Moab, UT, USA.
  • Vidoli G; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
  • Steadman D; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
  • Lynne AM; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
  • Bucheli S; Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO, USA.
  • Dorrestein PC; Forensic Investigation Research Station, Colorado Mesa University, Grand Junction, CO, USA.
  • Wrighton KC; Forensic Anthropology Center, Department of Anthropology, University of Tennessee, Knoxville, TN, USA.
  • Carter DO; Department of Social, Cultural, and Justice Studies, University of Tennessee at Chattanooga, Chattanooga, TN, USA.
  • Knight R; Forensic Anthropology Center, Department of Anthropology, University of Tennessee, Knoxville, TN, USA.
  • Metcalf JL; Mid-America College of Funeral Service, Jeffersonville, IN, USA.
Nat Microbiol ; 9(3): 595-613, 2024 Mar.
Article en En | MEDLINE | ID: mdl-38347104
ABSTRACT
Microbial breakdown of organic matter is one of the most important processes on Earth, yet the controls of decomposition are poorly understood. Here we track 36 terrestrial human cadavers in three locations and show that a phylogenetically distinct, interdomain microbial network assembles during decomposition despite selection effects of location, climate and season. We generated a metagenome-assembled genome library from cadaver-associated soils and integrated it with metabolomics data to identify links between taxonomy and function. This universal network of microbial decomposers is characterized by cross-feeding to metabolize labile decomposition products. The key bacterial and fungal decomposers are rare across non-decomposition environments and appear unique to the breakdown of terrestrial decaying flesh, including humans, swine, mice and cattle, with insects as likely important vectors for dispersal. The observed lockstep of microbial interactions further underlies a robust microbial forensic tool with the potential to aid predictions of the time since death.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Microbiología del Suelo / Consorcios Microbianos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Microbiología del Suelo / Consorcios Microbianos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nat Microbiol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos