Impact of peri-operative red blood cell transfusions for treatment of anemia on acute rejection in renal transplant recipients.
Transfus Apher Sci
; 63(3): 103896, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38365525
ABSTRACT
INTRODUCTION:
Anemia occurs before and after kidney transplantation. Determining the impact of perioperative transfusion on post-transplant outcomes can help determine best management of anemia. PROJECTAIM:
The current study aims to describe clinical outcomes associated with packed red blood cell transfusions in the peri-operative management of anemia after transplantation.DESIGN:
This was a single-center, retrospective study of adult kidney recipients with anemia at the time of transplantation. 1271 patients were stratified by donor-type due to the potential variability in underlying recipient and transplant characteristics; living donor (n = 698, 62%) or deceased donor (n = 573, 38%).RESULTS:
Living donor recipients that received blood during the index hospitalization were more likely to experience rejection within 30 days (18% vs. 10%, p = 0.008) and 1 year of transplant (32% vs. 16%, p = 0.038). In multivariate analysis, receiving both blood and darbepoetin (HR 1.89 [1.20,3.00], p = 0.006), age at transplant (HR 0.98 [0.97, 0.99], p = 0.02), number of HLA mismatches (HR 1.17 [1.05,1.30], p = 0.003), and whether the case was a repeat transplant (HR 2.77 [1.93,3.97], p < 0.01) were significantly associated with hazard of rejection. For deceased donor recipients, there were no differences in acute rejection, graft failure or mortality at 30 days or 1 year. When analyzing hazard of rejection in a multivariate model, treatment received was not found to be significantly associated with rejection.CONCLUSION:
Our findings suggest there may be a role for more aggressive pre-transplant treatment of anemia for those patients undergoing living donor transplants.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Riñón
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Transfusión de Eritrocitos
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Rechazo de Injerto
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Anemia
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Transfus Apher Sci
Asunto de la revista:
HEMATOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos