Major gangliosides in normal and pathological human thyroids.
Biochem Int
; 10(4): 531-8, 1985 Apr.
Article
en En
| MEDLINE
| ID: mdl-3839677
ABSTRACT
The major gangliosides of human thyroids were extracted, purified and then analyzed by gas-liquid chromatography. In normal thyroid, GM3 and GD3 represented about 80% of lipid-bound sialic acid. GM3 contained more than 50% of long-chain fatty acids, whereas GD3 contained mostly short ones. 4D hydroxy sphinganine represented 20% of long-chain base content in both cases. In pathological thyroids (Graves' disease, cancer, toxic adenoma), GM3 represented about 60% of lipid-bound sialic acid; its fatty acid content was mostly short chain fatty acids, as in normal GD3. 4D hydroxy sphinganine proportion was decreased.
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedades de la Tiroides
/
Glándula Tiroides
/
Gangliósidos
Límite:
Humans
Idioma:
En
Revista:
Biochem Int
Año:
1985
Tipo del documento:
Article