Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy.
J Perinat Med
; 52(4): 399-405, 2024 May 27.
Article
en En
| MEDLINE
| ID: mdl-38404246
ABSTRACT
OBJECTIVES:
This study aims to show the relation between biomarkers in maternal and cord-blood samples and fetal heart rate variability (fHRV) metrics through a non-invasive fetal magnetocardiography (fMCG) technique.METHODS:
Twenty-three women were enrolled for collection of maternal serum and fMCG tracings immediately prior to their scheduled cesarean delivery. The umbilical cord blood was collected for measurement of biomarker levels. The fMCG metrics were then correlated to the biomarker levels from the maternal serum and cord blood.RESULTS:
Brain-derived neurotrophic factor (BDNF) had a moderate correlation with fetal parasympathetic activity (0.416) and fetal sympathovagal ratios (-0.309; -0.356). Interleukin (IL)-6 also had moderate-sized correlations but with an inverse relationship as compared to BDNF. These correlations were primarily in cord-blood samples and not in the maternal blood.CONCLUSIONS:
In this small sample-sized exploratory study, we observed a moderate correlation between fHRV and cord-blood BDNF and IL-6 immediately preceding scheduled cesarean delivery at term. These findings need to be validated in a larger population.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Frecuencia Cardíaca Fetal
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Biomarcadores
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Interleucina-6
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Factor Neurotrófico Derivado del Encéfalo
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Sangre Fetal
Límite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Perinat Med
/
J. perinat. med
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Journal of perinatal medicine
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos