Nickel-catalyzed acylation of vinylpyridine with alkylzincs under 1 atm CO.
Org Biomol Chem
; 22(12): 2380-2383, 2024 Mar 20.
Article
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| MEDLINE
| ID: mdl-38436087
ABSTRACT
A nickel-catalyzed acylation of vinylpyridines with CO at atmospheric pressure is reported, allowing for an expedient approach to synthesize ß-acyl pyridine derivatives with high regio- and chemoselectivity. The electron-withdrawing property of pyridine plays pivotal roles in activating the alkenyl group, thereby facilitating this carbonylative process. In addition to vinylpyridines, other alkenylheterocycles such as thiazole and quinoline were also suitable for this method.
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MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2024
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Article