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Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study.
Zinellu, Angelo; Zoroddu, Stefano; Fois, Simona; Mellino, Sabrina; Scala, Chiara; Virdis, Erika; Zinellu, Elisabetta; Sotgia, Salvatore; Paliogiannis, Panagiotis; Mangoni, Arduino A; Carru, Ciriaco; Pirina, Pietro; Fois, Alessandro G.
Afiliación
  • Zinellu A; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
  • Zoroddu S; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
  • Fois S; Department of Respiratory Diseases, University Hospital Sassari (AOU), 07100 Sassari, Italy.
  • Mellino S; Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
  • Scala C; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
  • Virdis E; Department of Respiratory Diseases, University Hospital Sassari (AOU), 07100 Sassari, Italy.
  • Zinellu E; Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
  • Sotgia S; Department of Respiratory Diseases, University Hospital Sassari (AOU), 07100 Sassari, Italy.
  • Paliogiannis P; Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
  • Mangoni AA; Department of Respiratory Diseases, University Hospital Sassari (AOU), 07100 Sassari, Italy.
  • Carru C; Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
  • Pirina P; Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
  • Fois AG; Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Antioxidants (Basel) ; 13(3)2024 Feb 25.
Article en En | MEDLINE | ID: mdl-38539812
ABSTRACT
There are increasing efforts to better predict adverse outcomes for idiopathic pulmonary fibrosis (IPF). Our aim was to assess the prognostic potential of ischemia-modified albumin (IMA), an established circulating marker of ischemia and, more recently, oxidative stress, in a cohort of 56 IPF patients recruited between 2015 and 2023 at the University of Sassari, Italy. Demographic and functional parameters and serum IMA concentrations were measured at baseline. Non-survivors had significantly higher IMA concentrations vs. survivors (508 ± 64 vs. 474 ± 42 mABSU, respectively; p = 0.035). The Kaplan-Meier analysis showed a significant association between higher IMA values and poor survival (HR 3.32, 95% CI from 1.06 to 10.4, p = 0.039). In the Cox regression analysis, this association remained significant after adjusting for the force expiratory volume at 1 s, the total lung capacity, lymphocyte count, and pharmacological treatment (HR 1.0154, 95% CI from 1.0035 to 1.0275, p = 0.01). IMA, an oxidative stress biomarker measurable using relatively simple and available methods, is independently associated with mortality in IPF. Therefore, its determination may enhance risk stratification and treatment decisions. Prospective studies involving larger cohorts are needed to confirm this association and to endorse the use of IMA in routine practice.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia