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The Relative Cerebral Blood Volume (rCBV) < 42% Is Independently Associated with Collateral Status in Anterior Circulation Large Vessel Occlusion.
Lakhani, Dhairya A; Balar, Aneri B; Koneru, Manisha; Wen, Sijin; Ozkara, Burak Berksu; Lu, Hanzhang; Wang, Richard; Hoseinyazdi, Meisam; Mei, Janet; Xu, Risheng; Nabi, Mehreen; Mazumdar, Ishan; Cho, Andrew; Chen, Kevin; Sepehri, Sadra; Hyson, Nathan; Urrutia, Victor; Luna, Licia; Hillis, Argye E; Heit, Jeremy J; Albers, Greg W; Rai, Ansaar T; Dmytriw, Adam A; Faizy, Tobias; Wintermark, Max; Nael, Kambiz; Yedavalli, Vivek S.
Afiliación
  • Lakhani DA; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Balar AB; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Koneru M; Cooper Medical School, Rowan University, Camden, NJ 08103, USA.
  • Wen S; Department of Biostatistics, West Virginia University, Morgantown, WV 26506, USA.
  • Ozkara BB; Department of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Lu H; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Wang R; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Hoseinyazdi M; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Mei J; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Xu R; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Nabi M; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Mazumdar I; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Cho A; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Chen K; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Sepehri S; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Hyson N; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Urrutia V; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Luna L; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Hillis AE; Department of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Heit JJ; Department of Neurology, Stanford University, Stanford, CA 94305, USA.
  • Albers GW; Department of Neurology, Stanford University, Stanford, CA 94305, USA.
  • Rai AT; Department of Neuroradiology, West Virginia University, Morgantown, WV 26506, USA.
  • Dmytriw AA; Department of Radiology, Harvarvd Medical School, Boston, MA 02115, USA.
  • Faizy T; Department of Radiology, Neuroendovascular Division, University Medical Center Münster, 48149 Münster, Germany.
  • Wintermark M; Department of Neuroradiology, MD Anderson Medical Center, Houston, TX 77030, USA.
  • Nael K; Division of Neuroradiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
  • Yedavalli VS; Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
J Clin Med ; 13(6)2024 Mar 10.
Article en En | MEDLINE | ID: mdl-38541813
ABSTRACT

Background:

The pretreatment CT perfusion (CTP) marker the relative cerebral blood volume (rCBV) < 42% lesion volume has recently been shown to predict 90-day functional outcomes; however, studies assessing correlations of the rCBV < 42% lesion volume with other outcomes remain sparse. Here, we aim to assess the relationship between the rCBV < 42% lesion volume and the reference standard digital subtraction angiography (DSA)-derived American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN) collateral score, hereby referred as the DSA CS.

Methods:

In this retrospective evaluation of our prospectively collected database, we included acute stroke patients triaged by multimodal CT imaging, including CT angiography and perfusion imaging, with confirmed anterior circulation large vessel occlusion between 1 September 2017 and 1 October 2023. Group differences were assessed using the Student's t test, Mann-Whitney U test and Chi-Square test. Spearman's rank correlation and logistic regression analyses were used to assess associations between rCBV < 42% and DSA CS.

Results:

In total, 222 patients (median age 69 years, 56.3% female) met our inclusion criteria. In the multivariable logistic regression analysis, taking into account age, sex, race, hypertension, hyperlipidemia, diabetes, atrial fibrillation, prior stroke or transient ischemic attack, the admission National Institute of Health stroke scale, the premorbid modified Rankin score, the Alberta stroke program early CT score (ASPECTS), and segment occlusion, the rCBV < 42% lesion volume (adjusted OR 0.98, p < 0.05) was independently associated with the DSA CS.

Conclusion:

The rCBV < 42% lesion volume is independently associated with the DSA CS.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: J Clin Med Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos