The role of methadone in cardiac surgery for management of postoperative pain.
BJA Open
; 10: 100270, 2024 Jun.
Article
en En
| MEDLINE
| ID: mdl-38560623
ABSTRACT
Background:
This retrospective study evaluated the efficacy and safety of intraoperative methadone compared with short-acting opioids.Methods:
Patients undergoing cardiac surgery with cardiopulmonary bypass (n=11 967) from 2018 to 2023 from a single health system were categorised into groups based on intraoperative opioid administration no methadone (Group O), methadone plus other opioids (Group M+O), and methadone only (Group M).Results:
Patients in Groups M and M+O had lower mean pain scores until postoperative day (POD) 7 compared with Group O after adjusting for covariates (P<0.01). Both Groups M and M+O had lower total opioid administered compared with Group O for all days POD0-POD6 (all P<0.001). The median number of hours until initial postoperative opioid after surgery was 2.55 (inter-quartile range [IQR]=1.07-5.12), 6.82 (IQR=3.52-12.98), and 7.0 (IQR=3.82-12.95) for Group O, Group M+O, and Group M, respectively. The incidence of postoperative complications did not differ between groups.Conclusions:
Intraoperative administration of methadone was associated with better pain control without significant side-effects after cardiac surgery.
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Revista:
BJA Open
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos