Coronary slow flow and angiography-derived index of microcirculatory resistance as prognostic predictors in patients with angina and normal coronary arteries: a retrospective cohort study.
Acta Cardiol
; 79(2): 149-158, 2024 Apr.
Article
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| MEDLINE
| ID: mdl-38628089
ABSTRACT
BACKGROUND:
This study aims to investigate prognostic implications of coronary slow flow (CSF) and angiography-derived index of microcirculatory resistance (caIMR) in patients with angina and normal coronary arteries.METHODS:
A total of 582 patients were enrolled with angiographically normal coronary arteries. caIMR was calculated using a commercial software. Patients were followed up for a median of 45 months. The primary endpoint was defined as major adverse cardiovascular events (MACEs) comprising death, myocardial infarction and readmission for angina or heart failure.RESULTS:
CSF was diagnosed when TIMI grade 2 flow presented in at least one coronary artery. Multivariate analysis indicated TIMI-flow-based determination of CSF was not significantly associated with MACEs [hazard ratio (HR) 2.14; 95% confidence interval (CI) 0.87-5.31; p = 0.099), while caIMR >42 (HR 2.53; 95% CI 1.02-6.32; p = 0.047) were independent predictors of MACEs. Incorporation of caIMR improved the area under the curve from 0.587 to 0.642.CONCLUSIONS:
caIMR was an independent prognostic factor of long-term cardiovascular events in patients with CSF. Evaluation of caIMR improved the risk stratification of patients with angiographically-normal coronary arteries.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de la Arteria Coronaria
/
Vasos Coronarios
Límite:
Humans
Idioma:
En
Revista:
Acta Cardiol
Año:
2024
Tipo del documento:
Article