Altered fornix integrity is associated with sleep apnea-related hypoxemia in mild cognitive impairment.
Alzheimers Dement
; 20(6): 4092-4105, 2024 06.
Article
en En
| MEDLINE
| ID: mdl-38716833
ABSTRACT
INTRODUCTION:
The limbic system is critical for memory function and degenerates early in the Alzheimer's disease continuum. Whether obstructive sleep apnea (OSA) is associated with alterations in the limbic white matter tracts remains understudied.METHODS:
Polysomnography, neurocognitive assessment, and brain magnetic resonance imaging (MRI) were performed in 126 individuals aged 55-86 years, including 70 cognitively unimpaired participants and 56 participants with mild cognitive impairment (MCI). OSA measures of interest were the apnea-hypopnea index and composite variables of sleep fragmentation and hypoxemia. Microstructural properties of the cingulum, fornix, and uncinate fasciculus were estimated using free water-corrected diffusion tensor imaging.RESULTS:
Higher levels of OSA-related hypoxemia were associated with higher left fornix diffusivities only in participants with MCI. Microstructure of the other white matter tracts was not associated with OSA measures. Higher left fornix diffusivities correlated with poorer episodic verbal memory.DISCUSSION:
OSA may contribute to fornix damage and memory dysfunction in MCI. HIGHLIGHTS Sleep apnea-related hypoxemia was associated with altered fornix integrity in MCI. Altered fornix integrity correlated with poorer memory function. Sleep apnea may contribute to fornix damage and memory dysfunction in MCI.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fórnix
/
Imagen de Difusión Tensora
/
Disfunción Cognitiva
/
Hipoxia
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Alzheimers Dement
Año:
2024
Tipo del documento:
Article
País de afiliación:
Canadá