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CD73 polymorphisms are associated with schizophrenia.
Peng, He-Xia; Zhang, Li-Li; Jiang, Dan; Jian, Na; Zhang, Ting-Mei; Luo, Jia-Guo; Yin, Hai-Yan.
Afiliación
  • Peng HX; School of Acupuncture and Tuina, Chengdu University of Traditional Medicine, Chengdu, 610075, China.
  • Zhang LL; Chengdu Jinxin Mental Diseases Hospital, Chengdu, 610063, China.
  • Jiang D; School of Acupuncture and Tuina, Chengdu University of Traditional Medicine, Chengdu, 610075, China.
  • Jian N; Chengdu Jinxin Mental Diseases Hospital, Chengdu, 610063, China.
  • Zhang TM; School of Acupuncture and Tuina, Chengdu University of Traditional Medicine, Chengdu, 610075, China.
  • Luo JG; Chengdu Jinxin Mental Diseases Hospital, Chengdu, 610063, China.
  • Yin HY; School of Acupuncture and Tuina, Chengdu University of Traditional Medicine, Chengdu, 610075, China.
Purinergic Signal ; 2024 May 17.
Article en En | MEDLINE | ID: mdl-38758511
ABSTRACT
Ecto-5'-nucleotidase/CD73 enzyme plays a key role in the regulation of extracellular adenosine levels, thereby exerting influence on adenosine homeostasis. Emerging evidence suggests that perturbations in purines and ecto-5'-nucleotidase activity are associated with an augmented susceptibility to schizophrenia. However, the precise impact of genetic variations in CD73 on individuals with schizophrenia remains poorly understood. Here, our study demonstrated that rs3734442 allele and rs4431401 heterozygote were conferred a significant risk of schizophrenia disease (rs3734442 odds ratio, 0.556; 95% CI, 0.375 to 0.825; p = 0.004; rs4431401 odds ratio, 1.881, 95% CI, 1.117 to 3.166; p = 0.020). Comparing different genders, we observed a significant association between rs3734442 genotypes and male cases (rs3734442 odds ratio, 0.452; 95% CI, 0.257 to 0.796; p = 0.007). Likewise, there was a significant association between rs4431401 genotypes and male patients (rs4431401 odds ratio, 2.570; 95% CI, 1.196 to 5.522; p = 0.015). Based on family history and antipsychotics medication usage, our data reveals that the rs9444348 allele exhibits the most significant association with familial susceptibility to schizophrenia (odds ratio, 1.541; 95% CI, 1.009 to 2.353; p = 0.048 for A vs G). Moreover, individuals carrying variants of rs6922, rs2229523, and rs2065114 while being treated with clozapine demonstrate a higher frequency proportion compared to those receiving risperidone treatment (p = 0.035; p = 0.049; p = 0.027 respectively). Additionally, our results indicate that patients with GG genotype of rs9444348 had significantly higher likelihood of using clozapine instead of sulpiride (p = 0.048). Overall, our data strongly suggest that genetic variations in CD73 are significantly associated with schizophrenia risk and may serve as valuable resources for identifying therapeutic targets.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Purinergic Signal Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Purinergic Signal Año: 2024 Tipo del documento: Article País de afiliación: China