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Outbreak of multidrug-resistant Salmonella infections in people linked to pig ear pet treats, United States, 2015-2019: results of a multistate investigation.
Nichols, Megin; Stapleton, G Sean; Rotstein, David S; Gollarza, Lauren; Adams, Jennifer; Caidi, Hayat; Chen, Jessica; Hodges, April; Glover, Mark; Peloquin, Sarah; Payne, Lloyd; Norris, Anne; DeLancey, Siobhan; Donovan, Danielle; Dietrich, Steve; Glaspie, Stevie; McWilliams, Karen; Burgess, Elizabeth; Holben, Beth; Pietrzen, Karen; Benko, Scott; Feldpausch, Emily; Orel, Sydney; Neises, Daniel; Kline, Kelly E; Tobin, Bradley; Caron, Genevieve; Viveiros, Brendalee; Miller, Adam; Turner, Christina; Holmes-Talbot, Kimberly; Mank, Laurn; Nishimura, Christina; Nguyen, Tu Ngoc; Hale, Shelby; Francois Watkins, Louise K.
Afiliación
  • Nichols M; Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Stapleton GS; Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Rotstein DS; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
  • Gollarza L; Office of Surveillance and Compliance, Center for Veterinary Medicine, United States Food and Drug Administration, Rockville, MD, USA.
  • Adams J; Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Caidi H; Association of Public Health Laboratories, Silver Spring, MD, USA.
  • Chen J; Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Hodges A; Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Glover M; Office of Surveillance and Compliance, Center for Veterinary Medicine, United States Food and Drug Administration, Rockville, MD, USA.
  • Peloquin S; Office of Surveillance and Compliance, Center for Veterinary Medicine, United States Food and Drug Administration, Rockville, MD, USA.
  • Payne L; Veterinary Laboratory Investigation and Response Network, Office of Applied Science, Center for Veterinary Medicine, United States Food and Drug Administration, Laurel, MD, USA.
  • Norris A; Office of Surveillance and Compliance, Center for Veterinary Medicine, United States Food and Drug Administration, Rockville, MD, USA.
  • DeLancey S; Office of the Director, Strategic Communications, Center for Veterinary Medicine, United States Food and Drug Administration, Rockville, MD, USA.
  • Donovan D; Office of the Director, Strategic Communications, Center for Veterinary Medicine, United States Food and Drug Administration, Rockville, MD, USA.
  • Dietrich S; Michigan Department of Health & Human Services, Lansing, MI, USA.
  • Glaspie S; Michigan Department of Health & Human Services, Lansing, MI, USA.
  • McWilliams K; Michigan Department of Agriculture & Rural Development, MI, USA.
  • Burgess E; Michigan Department of Agriculture & Rural Development, MI, USA.
  • Holben B; Michigan Department of Health & Human Services, Lansing, MI, USA.
  • Pietrzen K; Michigan Department of Health & Human Services, Lansing, MI, USA.
  • Benko S; Michigan Department of Agriculture & Rural Development, MI, USA.
  • Feldpausch E; Michigan Department of Agriculture & Rural Development, MI, USA.
  • Orel S; Michigan Department of Agriculture & Rural Development, MI, USA.
  • Neises D; Kansas Department of Agriculture Laboratory, Manhattan, KS, USA.
  • Kline KE; Kansas Department of Health and Environment, Topeka, KS, USA.
  • Tobin B; Pennsylvania Department of Health, Harrisburg, PA, USA.
  • Caron G; Pennsylvania Department of Agriculture, Harrisburg, PA, USA.
  • Viveiros B; Rhode Island Department of Health, Providence, RI, USA.
  • Miller A; Rhode Island Department of Health, Providence, RI, USA.
  • Turner C; Rhode Island Department of Health, Providence, RI, USA.
  • Holmes-Talbot K; Connecticut Department of Public Health, Hartford, CT, USA.
  • Mank L; Connecticut Department of Public Health, Hartford, CT, USA.
  • Nishimura C; Connecticut Department of Public Health, Hartford, CT, USA.
  • Nguyen TN; Connecticut Department of Public Health, Hartford, CT, USA.
  • Hale S; Connecticut Department of Public Health, Hartford, CT, USA.
  • Francois Watkins LK; Ohio Department of Health, Columbus, OH, USA.
Lancet Reg Health Am ; 34: 100769, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38817954
ABSTRACT

Background:

International distribution of contaminated foods can be a source of Salmonella infections in people and can contribute to the spread of antimicrobial-resistant bacteria across countries. We report an investigation led by the United States Centers for Disease Control and Prevention, the Food and Drug Administration (FDA), and state governmental officials into a multistate outbreak of salmonellosis linked to pig ear pet treats.

Methods:

Pig ear treats and companion dogs were tested for Salmonella by state officials and the FDA. Products were traced back to the country of origin when possible. Cases were defined as outbreak illnesses in people associated with one of seven Salmonella serotypes genetically related to samples from pig ear pet treats, with isolation dates from June 2015 to September 2019. Whole genome sequencing (WGS) of isolates was used to predict antimicrobial resistance.

Findings:

The outbreak included 154 human cases in 34 states. Of these, 107 of 122 (88%) patients reported dog contact, and 65 of 97 (67%) reported contact with pig ear pet treats. Salmonella was isolated from 137 pig ear treats, including some imported from Argentina, Brazil, and Colombia, and from four dogs. WGS predicted 77% (105/137) of human and 43% (58/135) of pig ear treat isolates were resistant to ≥3 antimicrobial classes.

Interpretation:

This was the first documented United States multistate outbreak of Salmonella infections linked to pig ear pet treats. This multidrug-resistant outbreak highlights the interconnectedness of human health and companion animal ownership and the need for zoonotic pathogen surveillance to prevent human illness resulting from internationally transported pet food products.

Funding:

Animal Feed Regulatory Program Standards award. Animal and product testing conducted by FDA Vet-LIRN was funded by Vet-LIRN infrastructure grants (PAR-22-063).
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Lancet Reg Health Am Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Lancet Reg Health Am Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos