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Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo.
Vakaniaki, Emmanuel Hasivirwe; Kacita, Cris; Kinganda-Lusamaki, Eddy; O'Toole, Áine; Wawina-Bokalanga, Tony; Mukadi-Bamuleka, Daniel; Amuri-Aziza, Adrienne; Malyamungu-Bubala, Nadine; Mweshi-Kumbana, Franklin; Mutimbwa-Mambo, Léandre; Belesi-Siangoli, Freddy; Mujula, Yves; Parker, Edyth; Muswamba-Kayembe, Pauline-Chloé; Nundu, Sabin S; Lushima, Robert S; Makangara-Cigolo, Jean-Claude; Mulopo-Mukanya, Noella; Pukuta-Simbu, Elisabeth; Akil-Bandali, Prince; Kavunga, Hugo; Abdramane, Ombotimbe; Brosius, Isabel; Bangwen, Eugene; Vercauteren, Koen; Sam-Agudu, Nadia A; Mills, Edward J; Tshiani-Mbaya, Olivier; Hoff, Nicole A; Rimoin, Anne W; Hensley, Lisa E; Kindrachuk, Jason; Baxter, Cheryl; de Oliveira, Tulio; Ayouba, Ahidjo; Peeters, Martine; Delaporte, Eric; Ahuka-Mundeke, Steve; Mohr, Emma L; Sullivan, Nancy J; Muyembe-Tamfum, Jean-Jacques; Nachega, Jean B; Rambaut, Andrew; Liesenborghs, Laurens; Mbala-Kingebeni, Placide.
Afiliación
  • Vakaniaki EH; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Kacita C; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Kinganda-Lusamaki E; Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo.
  • O'Toole Á; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Wawina-Bokalanga T; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.
  • Mukadi-Bamuleka D; TransVIHMI (Recherches Translationnelles sur le VIH et les Maladies Infectieuses endémiques et émergentes), Université de Montpellier, French National Research Institute for Sustainable Development (IRD), INSERM, Montpellier, France.
  • Amuri-Aziza A; Institute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.
  • Malyamungu-Bubala N; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Mweshi-Kumbana F; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Mutimbwa-Mambo L; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.
  • Belesi-Siangoli F; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Mujula Y; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.
  • Parker E; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
  • Muswamba-Kayembe PC; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Nundu SS; Kamituga General Hospital, South Kivu, Democratic Republic of the Congo.
  • Lushima RS; Kamituga General Hospital, South Kivu, Democratic Republic of the Congo.
  • Makangara-Cigolo JC; Kamituga Health Zone, South Kivu, Democratic Republic of the Congo.
  • Mulopo-Mukanya N; Provincial Health Division, South Kivu, Democratic Republic of the Congo.
  • Pukuta-Simbu E; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Akil-Bandali P; African Center of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria.
  • Kavunga H; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Abdramane O; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Brosius I; Hemorrhagic Fever and Monkeypox Program, Ministry of Health, Kinshasa, Democratic Republic of the Congo.
  • Bangwen E; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Vercauteren K; Service de Microbiologie, Département de Biologie Médicale, Cliniques Universitaires de Kinshasa, Université de Kinshasa, Kinshasa, Democratic Republic of the Congo.
  • Sam-Agudu NA; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
  • Mills EJ; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Tshiani-Mbaya O; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Hoff NA; Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo.
  • Rimoin AW; Rodolphe Merieux INRB-Goma Laboratory, Goma, Democratic Republic of the Congo.
  • Hensley LE; Medical Department, The Alliance for International Medical Action, Goma, Democratic Republic of the Congo.
  • Kindrachuk J; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Baxter C; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • de Oliveira T; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  • Ayouba A; Department of Pediatrics and Child Health, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana.
  • Peeters M; International Research Center of Excellence, Institute of Human Virology Nigeria, Abuja, Nigeria.
  • Delaporte E; Global Pediatrics Program and Division of Infectious Diseases, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
  • Ahuka-Mundeke S; Department of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
  • Mohr EL; Frederick National Laboratory, Leidos Biomedical Research, Clinical Monitoring Research Program Directorate, Frederick, MD, USA.
  • Sullivan NJ; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA, USA.
  • Muyembe-Tamfum JJ; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA, USA.
  • Nachega JB; US Department of Agriculture, Manhattan, KS, USA.
  • Rambaut A; University of Manitoba, Winnipeg, Manitoba, Canada.
  • Liesenborghs L; Centre for Epidemic Response and Innovation, Stellenbosch University, Cape Town, South Africa.
  • Mbala-Kingebeni P; Centre for Epidemic Response and Innovation, Stellenbosch University, Cape Town, South Africa.
Nat Med ; 2024 Jun 13.
Article en En | MEDLINE | ID: mdl-38871006
ABSTRACT
Outbreaks of monkeypox (mpox) have historically resulted from zoonotic spillover of clade I monkeypox virus (MPXV) in Central Africa and clade II MPXV in West Africa. In 2022, subclade IIb caused a global epidemic linked to transmission through sexual contact. Here we describe the epidemiological and genomic features of an mpox outbreak in a mining region in eastern Democratic Republic of the Congo, caused by clade I MPXV. Surveillance data collected between September 2023 and January 2024 identified 241 suspected cases. Genomic analysis demonstrates a distinct clade I lineage divergent from previously circulating strains in the Democratic Republic of the Congo. Of the 108 polymerase chain reaction-confirmed mpox cases, the median age of individuals was 22 years, 51.9% were female and 29% were sex workers, suggesting a potential role for sexual transmission. The predominance of APOBEC3-type mutations and the estimated emergence time around mid-September 2023 imply recent sustained human-to-human transmission.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: República Democrática del Congo
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: República Democrática del Congo