Significant improvement of a nevus spilus-type congenital melanocytic nevus with oral selumetinib.

Berna, R; Hasbun, T; Adams, D; Moon, A T; Treat, J R

Berna, R; Hasbun, T; Adams, D; Moon, A T; Treat, J R.

Afiliación

Berna R; Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hasbun T; Dermatology Department, Clínica Alemana de Santiago - Facultad de Medicina Universidad del Desarrollo and Hospital Exequiel González Cortés, Santiago, Chile.
Adams D; Division of General Pediatrics, Section of Pediatric Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Moon AT; Division of General Pediatrics, Section of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Treat JR; Division of General Pediatrics, Section of Pediatric Dermatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Pediatr Dermatol ; 41(5): 936-937, 2024.

Article en En | MEDLINE | ID: mdl-38886992

ABSTRACT

ABSTRACT

Giant congenital melanocytic nevi (GCMN) can be cosmetically significant and can lead to melanoma. There is no standard pharmacologic treatment for GCMN. We present the case of an 8-year-old female with kaposiform lymphangiomatosis caused by an NRAS mutation whose nevus spilus-type GCMN improved on oral selumetinib.

Asunto(s)

Bencimidazoles; Nevo Pigmentado; Neoplasias Cutáneas; Humanos; Nevo Pigmentado/tratamiento farmacológico; Nevo Pigmentado/patología; Nevo Pigmentado/genética; Nevo Pigmentado/congénito; Femenino; Niño; Neoplasias Cutáneas/tratamiento farmacológico; Neoplasias Cutáneas/patología; Neoplasias Cutáneas/genética; Neoplasias Cutáneas/congénito; Bencimidazoles/uso terapéutico; Administración Oral; Mutación; GTP Fosfohidrolasas/genética; Proteínas de la Membrana/genética

Palabras clave

MEK inhibitor; NRAS; kaposiform lymphangiomatosis; nevus spilus

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Bencimidazoles / Nevo Pigmentado Límite: Child / Female / Humans Idioma: En Revista: Pediatr Dermatol Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos

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