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Acquired copy number amplification at the MYC enhancer in human B-precursor acute lymphoblastic leukemia cell lines.
Watanabe, Atsushi; Wang, Lu; Tan, Tze King; Urayama, Kevin Y; Kizuki, Toshihiko; Komatsu, Chiaki; Kagami, Keiko; Shinohara, Tamao; Kasai, Shin; Tamai, Minori; Harama, Daisuke; Akahane, Koshi; Goi, Kumiko; Goto, Hiroaki; Satou, Kazuhito; Kaname, Tadashi; Sanda, Takaomi; Inukai, Takeshi.
Afiliación
  • Watanabe A; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Wang L; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore.
  • Tan TK; Department of Pediatrics, Yamanashi Prefectural Central Hospital, Kofu, Japan.
  • Urayama KY; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore.
  • Kizuki T; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore.
  • Komatsu C; Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.
  • Kagami K; Graduate School of Public Health, St. Luke's International University, Tokyo, Japan.
  • Shinohara T; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Kasai S; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Tamai M; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Harama D; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Akahane K; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Goi K; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Goto H; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Satou K; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Kaname T; Department of Pediatrics, School of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Sanda T; Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
  • Inukai T; Department of Genome Medicine, National Center for Child Health and Development, Tokyo, Japan.
Cancer Sci ; 115(9): 3196-3199, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38923173
ABSTRACT
Our study highlights the discovery of recurrent copy number alterations in noncoding regions, specifically blood enhancer cluster (BENC-CNA), in B-precursor acute lymphoblastic leukemia (BCP-ALL) cell lines. We demonstrate that BENC-CNA acts as a super-enhancer, driving MYC expression and possibly contributing to the immortalization and proliferative advantage of BCP-ALL cells in vitro.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Proteínas Proto-Oncogénicas c-myc / Elementos de Facilitación Genéticos / Variaciones en el Número de Copia de ADN Límite: Humans Idioma: En Revista: Cancer Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Proteínas Proto-Oncogénicas c-myc / Elementos de Facilitación Genéticos / Variaciones en el Número de Copia de ADN Límite: Humans Idioma: En Revista: Cancer Sci Año: 2024 Tipo del documento: Article País de afiliación: Japón