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nnU-Net-based deep-learning for pulmonary embolism: detection, clot volume quantification, and severity correlation in the RSPECT dataset.
Lanza, Ezio; Ammirabile, Angela; Francone, Marco.
Afiliación
  • Lanza E; Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 4, Pieve Emanuele MI 20072, Italy; IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan 20089, Italy. Electronic address: ezio.lanza@humanitas.it.
  • Ammirabile A; Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 4, Pieve Emanuele MI 20072, Italy; IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan 20089, Italy.
  • Francone M; Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini, 4, Pieve Emanuele MI 20072, Italy; IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, Milan 20089, Italy.
Eur J Radiol ; 177: 111592, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38968751
ABSTRACT

OBJECTIVES:

CT pulmonary angiography is the gold standard for diagnosing pulmonary embolism, and DL algorithms are being developed to manage the increase in demand. The nnU-Net is a new auto-adaptive DL framework that minimizes manual tuning, making it easier to develop effective algorithms for medical imaging even without specific expertise. This study assesses the performance of a locally developed nnU-Net algorithm on the RSPECT dataset for PE detection, clot volume measurement, and correlation with right ventricle overload. MATERIALS &

METHODS:

User input was limited to segmentation using 3DSlicer. We worked with the RSPECT dataset and trained an algorithm from 205 PE and 340 negatives. The test dataset comprised 6573 exams. Performance was tested against PE characteristics, such as central, non-central, and RV overload. Blood clot volume (BCV) was extracted from each exam. We employed ROC curves and logistic regression for statistical validation.

RESULTS:

Negative studies had a median BCV of 1 µL, which increased to 345 µL in PE-positive cases and 7,378 µL in central PEs. Statistical analysis confirmed a significant BCV correlation with PE presence, central PE, and increased RV/LV ratio (p < 0.0001). The model's AUC for PE detection was 0.865, with an 83 % accuracy at a 55 µL threshold. Central PE detection AUC was 0.937 with 91 % accuracy at 850 µL. The RV overload AUC stood at 0.848 with 79 % accuracy.

CONCLUSION:

The nnU-Net algorithm demonstrated accurate PE detection, particularly for central PE. BCV is an accurate metric for automated severity stratification and case prioritization. CLINICAL RELEVANCE STATEMENT The nnU-Net framework can be utilized to create a dependable DL for detecting PE. It offers a user-friendly approach to those lacking expertise in AI and rapidly extracts the Blood Clot Volume, a metric that can evaluate the PE's severity.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Embolia Pulmonar / Angiografía por Tomografía Computarizada / Aprendizaje Profundo Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Radiol Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Embolia Pulmonar / Angiografía por Tomografía Computarizada / Aprendizaje Profundo Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Radiol Año: 2024 Tipo del documento: Article