Mucosal Site Detection of Herpes Simplex Virus in Neonates.

Graf, Rachel J; Viviana Hoyos García, Ingrith; Dendi, Alvaro; White, Natalie O; Pifer, Traci; Harris, Rachelle; Salamon, Douglas; Mejias, Asuncion; Sánchez, Pablo J

Graf, Rachel J; Viviana Hoyos García, Ingrith; Dendi, Alvaro; White, Natalie O; Pifer, Traci; Harris, Rachelle; Salamon, Douglas; Mejias, Asuncion; Sánchez, Pablo J.

Afiliación

Graf RJ; The Ohio State University College of Medicine, Columbus, OH; Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH.
Viviana Hoyos García I; Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH; Department of Pediatrics, Hospital Universitario del Valle, Universida
Dendi A; Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH; Department of Neonatology, Centro Hospitalario Pereira Rossell, Univer
White NO; Pediatrix Medical Group of Ohio, Columbus, OH.
Pifer T; Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH; Division of Pediatric Infectious Diseases, Department of Pediatrics, N
Harris R; Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH.
Salamon D; Department of Laboratory Medicine, Microbiology Laboratory, Nationwide Children's Hospital, Columbus, OH.
Mejias A; Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN.
Sánchez PJ; The Ohio State University College of Medicine, Columbus, OH; Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH; Division

J Pediatr ; 275: 114212, 2024 Jul 24.

Article en En | MEDLINE | ID: mdl-39059717

ABSTRACT

ABSTRACT

From 2001 to 2023, 17 (14%) of 120 neonates with confirmed herpes simplex virus infection tested positive for herpes simplex virus by polymerase chain reaction (PCR) from only mucosal sites without a clinical mucosal lesion. Whether mucosal PCR positivity reflects early infection that may lead to recognizable disease, transient colonization, or a false-positive PCR result remains a clinical conundrum and warrants further study.

Palabras clave

PCR; acyclovir; neonatal herpes; neonate

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