Creatine kinase release not associated with myocardial necrosis after short periods of coronary artery occlusion in conscious baboons.
J Am Coll Cardiol
; 6(6): 1299-303, 1985 Dec.
Article
en En
| MEDLINE
| ID: mdl-4067108
ABSTRACT
The effects of 15 minute periods of coronary artery occlusion on plasma creatine kinase (CK) and CK-MB isoenzyme activity, regional myocardial function and subsequent myocardial necrosis were studied in six conscious baboons 2 to 3 weeks after recovery from instrumentation. Mid left anterior descending coronary artery occlusion induced complete loss of systolic wall thickening (ultrasound transit time technique) and decreases in epicardial (-93%) and endocardial (-96%) blood flows (microsphere technique). Reperfusion after 15 minutes resulted in complete recovery of regional function 24 hours later. Serial plasma enzyme activity revealed a significant increase in total CK from 71 +/- 11 to 976 +/- 158 U/liter and in CK-MB from levels that were too low to measure to 21.4 +/- 2.9 U/liter. At autopsy, neither gross pathologic evidence (triphenyltetrazolium chloride staining technique) nor histologic evidence of myocardial necrosis was observed. Thus, in the conscious baboon short episodes of myocardial ischemia are associated with a significant appearance of CK and CK-MB in the blood in the absence of cellular necrosis.
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Banco de datos:
MEDLINE
Asunto principal:
Circulación Coronaria
/
Enfermedad Coronaria
/
Creatina Quinasa
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
J Am Coll Cardiol
Año:
1985
Tipo del documento:
Article