Specific assay of aminoglycosidic- or polymyxin-type antibiotics present in human sera in combination with cephalosporins.
Appl Microbiol
; 21(6): 1002-6, 1971 Jun.
Article
en En
| MEDLINE
| ID: mdl-4327609
ABSTRACT
Monitoring of serum concentrations of aminoglycosidic or polymyxin antibiotics when administered concurrently with cephalosporins or penicillins requires a special assay technique. Selective enzymatic degradation of the beta-lactam antibiotic from the serum specimen allows subsequent assay of the antibiotic being monitored. This report gives details of a simple procedure for laboratory production of a crude enzyme capable of degrading cephalosporins or penicillins. An assay procedure for quantitating aminoglycosidic or polymyxin antibiotics after enzymatic degradation of a coexisting beta-lactam antibiotic is described.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Bioensayo
/
Gentamicinas
/
Kanamicina
/
Estreptomicina
/
Cefalosporinas
/
Colistina
/
Polimixinas
/
Antibacterianos
Límite:
Humans
Idioma:
En
Revista:
Appl Microbiol
Año:
1971
Tipo del documento:
Article