Effect of diazepam on plasma corticosterone levels.
Psychopharmacology (Berl)
; 83(1): 79-81, 1984.
Article
en En
| MEDLINE
| ID: mdl-6429704
ABSTRACT
In light of the numerous but rather conflicting reports on the action of benzodiazepines upon the hypothalamo-hypophyseal-adrenal (HHA) axis activity, the effect of different doses of diazepam (0.1, 1.0 and 10.0 mg/kg) administered 15, 30, 60, 120 and 240 min before decapitation on plasma corticosterone level was studied in rats. While 0.1 mg/kg diazepam had no effect, 1.0 mg/kg diazepam decreased plasma corticosterone levels 30 and 60 min following drug administration. On the other hand, treatment with 10.0 mg/kg diazepam produced an increase in plasma corticosterone levels from 15-120 min following drug administration.
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Banco de datos:
MEDLINE
Asunto principal:
Corticosterona
/
Diazepam
Límite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Año:
1984
Tipo del documento:
Article