Effect on hemoglobin A1 of rapid normalization of glycemia with an artificial endocrine pancreas.
Mayo Clin Proc
; 56(6): 377-80, 1981 Jun.
Article
en En
| MEDLINE
| ID: mdl-7230900
ABSTRACT
Six insulin-requiring chronically hyperglycemic diabetic patients underwent glucose control for 72 hours with an artificial endocrine pancreas, the Biostator Glucose Controller. Euglycemia was within 4 hours and was maintained (110 leads to 2 mg/dl) thereafter. The concentration of hemoglobin A (HbA) was elevated, at 12.5 leads to 0.6%, at the initiation of Biostator treatment. Decreases in HbA, of 0.5 leads to 0.1% (P less than 0.01) were observed within 4 hours of Biostator therapy. Over the first 16 hours, the slope was less steep, -0.018 leads to 0.004% per hour (P less than 0.01). After 72 hours, decreases in HbA of 1.8 leads to 0.4% (P less than 0.01) were observed. The current concept of HbA as an indication of integrated glycemia over weeks and months requires modification to account for a small, rapidly reversible component. Interpretation of the value of HbA when measured by a kit method must take into consideration that small changes in HbA may occur over a few hours as a result of a large and persistent change in glycemia.
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Banco de datos:
MEDLINE
Asunto principal:
Páncreas
/
Órganos Artificiales
/
Hemoglobina A
/
Glicósidos
/
Hiperglucemia
Límite:
Adolescent
/
Adult
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Mayo Clin Proc
Año:
1981
Tipo del documento:
Article