Growth modulation of human prostatic cancer cells by interleukin-1 and interleukin-1 receptor antagonist.
Cancer Lett
; 95(1-2): 119-23, 1995 Aug 16.
Article
en En
| MEDLINE
| ID: mdl-7656219
ABSTRACT
The effects of interleukin-1 (IL-1 alpha or IL 1 beta) on androgen-dependent LNCaP and androgen-independent JCA-1 human prostatic cancer cell proliferation were investigated. IL-1 alpha or IL-1 beta induced a dose dependent growth reduction by 50-80% as determined by cell cycle phase distribution, cell number and clonal growth in short and long term cultures. IL-1 negated the androgen growth effect on equal molar basis but the androgen receptors were not blocked by IL-1. The presence of intracellular IL-1 receptors was detected by flow cytometry and the IL-1 mediated growth reduction could be blocked with a 500 fold excess of the IL-1 receptor antagonist (hIL-1ra), revealing a growth control involving IL-1, HIL-1ra, androgen and their receptors.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Próstata
/
Sialoglicoproteínas
/
División Celular
/
Interleucina-1
/
Receptores de Interleucina-1
Límite:
Humans
/
Male
Idioma:
En
Revista:
Cancer Lett
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos