Myocardial kinetics of TcN-NOET: a neutral lipophilic complex tracer of regional myocardial blood flow.
J Nucl Med
; 36(6): 1069-77, 1995 Jun.
Article
en En
| MEDLINE
| ID: mdl-7769430
ABSTRACT
UNLABELLED [Bis (N-etoxy, N ethyl dithiocarbamato) nitrido] 99mTc (V) (TcN-NOET) is a new neutral lipophilic myocardial imaging agent proposed for clinical use for detecting coronary artery disease. We studied the relation between myocardial retention of TcN-NOET and myocardial blood flow (MBF) in a canine model. METHODS:
A wide range of MBF was induced by partial regional coronary occlusion and dipyridamole infusion (protocols 1,2 and 3). Myocardial activity of TcN-NOET was determined by in vitro tissue counting at 15 or 90 min postinjection. Tracer activity was correlated with radiolabeled microspheres using linear regression analysis.RESULTS:
There was a linear correlation between myocardial TcN-NOET activity and microspheres in protocol 1 (r = 094, 15 min postinjection, protocol 2 (r = 0.94, 15 min postinjection after dipyridamole) and protocol 3 (r = 0.91, 90 min postinjection after dipyridamole). When arterial occlusion was discontinued (protocol 4), there was no longer a close linear correlation (r = 0.26). The first-pass myocardial extraction action of TcN-NOET was 75.5% +/- 4% under basal conditions and 85% +/- 2% under hyperemic conditions (p < 0.01).CONCLUSION:
Up to 90 min after injection, the relationship between TcN-NOET myocardial retention and blood flow is excellent over a wide range of flows. After reflow, TcN-NOET redistributes almost completely within 90 min.
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Banco de datos:
MEDLINE
Asunto principal:
Tiocarbamatos
/
Compuestos de Organotecnecio
/
Circulación Coronaria
/
Corazón
Tipo de estudio:
Guideline
Límite:
Animals
Idioma:
En
Revista:
J Nucl Med
Año:
1995
Tipo del documento:
Article
País de afiliación:
Francia