Effects of alprazolam on influenza virus infection in stressed mice.
Pharmacol Biochem Behav
; 46(1): 167-72, 1993 Sep.
Article
en En
| MEDLINE
| ID: mdl-8255908
ABSTRACT
The review of the literature shows that stress can adversely affect influenza A virus infection. In this report, we study the effects of chronic alprazolam (1 mg/kg/day), a central benzodiazepine agonist anxiolytic, on the influenza A (PR-8/34) virus specific immune injury in mice exposed to a chronic auditory stressor. Treatment with alprazolam resulted in a significant reduction of stress-induced increase of virus titters and pulmonary vascular permeability. A correlation with the lethality of mice was also observed.
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Banco de datos:
MEDLINE
Asunto principal:
Virus de la Influenza A
/
Estrés Psicológico
/
Alprazolam
/
Infecciones por Orthomyxoviridae
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1993
Tipo del documento:
Article
País de afiliación:
España