The phorbol derivatives thymeleatoxin and 12-deoxyphorbol-13-O-phenylacetate-10-acetate cause translocation and down-regulation of multiple protein kinase C isozymes.
FEBS Lett
; 319(1-2): 31-4, 1993 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-8454058
ABSTRACT
Phorbol esters such as phorbol 12-myristate,13-acetate (PMA) are potent activators of protein kinase C (PKC), and activate all PKC isozymes except zeta and lambda. Recently, 12-deoxyphorbol-13-O-phenylacetate-20-acetate (dPPA) and thymeleatoxin (Tx) were reported to selectively activate PKC beta 1 (dPPA) and PKC alpha, -beta, and -gamma (Tx), but not PKC delta or PKC epsilon in vitro. We examined the ability of these phorbol derivatives to translocate and down-regulate PKC isozymes in intact cells. Our findings demonstrate that dPPA and Tx cause translocation and down-regulation of multiple PKC isozymes, including delta and epsilon.
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Banco de datos:
MEDLINE
Asunto principal:
Proteína Quinasa C
/
Ésteres del Forbol
/
Acetato de Tetradecanoilforbol
/
Isoenzimas
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1993
Tipo del documento:
Article