The base excision repair pathway.

Seeberg, E; Eide, L; Bjørås, M

Seeberg, E; Eide, L; Bjørås, M.

Afiliación

Seeberg E; Ecole Supérieure de Biotechnologie de Strasbourg, UPR9003 de CNRS, Unité de Cancérogenèse et de Mutagenèse Moléculaire et Structurale, Illkirch-Graffenstaden, France.

Trends Biochem Sci ; 20(10): 391-7, 1995 Oct.

Article en En | MEDLINE | ID: mdl-8533150

ABSTRACT

ABSTRACT

The base excision repair pathway has evolved to protect cells from the deleterious effects of endogenous DNA damage induced by hydrolysis, reactive oxygen species and other intracellular metabolites that modify DNA base structure. However, base excision repair is also important to resist lesions produced by ionizing radiation and strong alkylating agents, which are similar to those induced by endogenous factors.

Asunto(s)

Reparación del ADN; Modelos Genéticos; Adenina; Alquilación; Secuencia de Aminoácidos; Composición de Base; Citosina; Daño del ADN; Endodesoxirribonucleasas; Hidrólisis; Datos de Secuencia Molecular; N-Glicosil Hidrolasas; Purinas; Uracilo

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Banco de datos: MEDLINE Asunto principal: Reparación del ADN / Modelos Genéticos Tipo de estudio: Prognostic_studies Idioma: En Revista: Trends Biochem Sci Año: 1995 Tipo del documento: Article País de afiliación: Francia

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