Evolutionary origin of nonuniversal CUGSer codon in some Candida species as inferred from a molecular phylogeny.
Genetics
; 141(3): 903-7, 1995 Nov.
Article
en En
| MEDLINE
| ID: mdl-8582635
ABSTRACT
CUG, a universal leucine codon, has been reported to be read as serine in various yeast species belonging to the genus Candida. To gain a deeper insight into the origin of this deviation from the universal genetic code, we carried out a phylogenetic analysis based on the small-subunit ribosomal RNA genes from some Candida and other related Hemiascomycetes. Furthermore, we determined the phylogenetic relationships between the tRNA(Ser)CAG, responsible for the translation of CUG, from some Candida species and the other serine and leucine isoacceptor tRNAs in C. cylindracea. We demonstrate that the group of Candida showing the genetic code deviation is monophyletic and that this deviation could have originated more than 150 million years ago. We also describe how phylogenetic analysis can be used for genetic code predictions.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Filogenia
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Serina
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Candida
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Codón
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Código Genético
Idioma:
En
Revista:
Genetics
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia