CRNF, a molluscan neurotrophic factor that interacts with the p75 neurotrophin receptor.
Science
; 274(5292): 1540-3, 1996 Nov 29.
Article
en En
| MEDLINE
| ID: mdl-8929417
ABSTRACT
A 13.1-kilodalton protein, cysteine-rich neurotrophic factor (CRNF), was purified from the mollusk Lymnaea stagnalis by use of a binding assay on the p75 neurotrophin receptor. CRNF bound to p75 with nanomolar affinity but was not similar in sequence to neurotrophins or any other known gene product. CRNF messenger RNA expression was highest in adult foot subepithelial cells; in the central nervous system, expression was regulated by lesion. The factor evoked neurite outgrowth and modulated calcium currents in pedal motor neurons. Thus, CRNF may be involved in target-derived trophic support for motor neurons and could represent the prototype of another family of p75 ligands.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Factor de Crecimiento Nervioso
/
Lymnaea
/
Factores de Crecimiento Nervioso
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1996
Tipo del documento:
Article
País de afiliación:
Suecia