The effects of 'sleep promoting agents' on behavioural state in the ovine fetus.
Brain Res Dev Brain Res
; 103(1): 1-8, 1997 Oct 20.
Article
en En
| MEDLINE
| ID: mdl-9370055
ABSTRACT
Fetal behavioural states, with similarities to adult sleep states, exist in both the human and ovine fetus near term. The purpose of the present study was to determine the effects of intracerebral administration of pharmacologic agents, known to affect sleep states in the adult, on fetal behavioural states and physiologic correlates using the chronically catheterized ovine fetus near term. Each drug was infused into either the cisterna magna or lateral ventricle for 90 min in one of two doses. Carbachol (1.35 x 10(-5) and 4.25 x 10(-6) M) led to an increase in low-voltage ECOG, eye movement and FBM activities, while scopolamine (4.68 x 10(-4) and 1.56 x 10(-4) M) led to a decrease in low-voltage ECOG and eye movement activity with an increase in high-voltage ECOG activity. L-5-Hydroxytryptophan (5-HTP) (2.04 x 10(-3) and 6.81 x 10(-4) M) infusion led to an increase in FBM, while VIP (3.00 x 10(-7) and 1.00 x 10(-7) M) infusion had no effect on fetal behavioural state parameters. Study results indicate that fetal behavioural states can be altered pharmacologically and in a manner similar to that seen in the adult but with notable differences that may relate to species, developmental or dose-response issues.
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Banco de datos:
MEDLINE
Asunto principal:
Escopolamina
/
Sueño
/
Carbacol
/
Péptido Intestinal Vasoactivo
/
5-Hidroxitriptófano
/
Feto
Límite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Brain Res Dev Brain Res
Asunto de la revista:
CEREBRO
/
NEUROLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Canadá