Detection of an inhibiting activity for osteoclast bone resorption from human prostatic cancer cells.
Cancer Lett
; 123(1): 15-20, 1998 Jan 16.
Article
en En
| MEDLINE
| ID: mdl-9461012
ABSTRACT
An inhibiting activity for isolated osteoclasts and bone resorption was demonstrated in culture supernatants from androgen-independent, but not androgen-dependent, human prostatic cancer cell lines. It causes a dose-dependent osteoclast inhibition as quantified with a bone resorbing pit formation assay. The constitutively released activity was determined to be protein (>50 kDa) distinct from some of the known cytokines in bone resorption. The activity does not affect osteoclast morphology and viability. Time-lapse video microscopy revealed an osteoclast motility increase, disrupting their anchorage to the bone and resorbing processes. The association of the activity with androgen-independent cancer cells that disrupt bone remodeling is discussed.
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Banco de datos:
MEDLINE
Asunto principal:
Osteoclastos
/
Neoplasias de la Próstata
/
Resorción Ósea
/
Carcinoma
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Cancer Lett
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos