Neurotrophic factors decrease the release of creatine kinase and prostaglandin E2 from metabolically stressed muscle.
Neuromuscul Disord
; 8(1): 7-13, 1998 Feb.
Article
en En
| MEDLINE
| ID: mdl-9565985
ABSTRACT
We have used an in vitro model of oxidative stress by exposing rat muscle to 24 dinitrophenol. This causes an efflux of creatine kinase (CK) and prostaglandin E2 (PGE2) commonly used as indicators of muscle cell damage. We then investigated compounds with a putative cell protective effect in the system. Ciliary neurotrophic factor, brain derived neurotrophic factor and insulin like growth factor 1 all prevent the release of PGE2 and CK. To the extent that these indicators may reflect cell damage, the results might support the investigation of the therapeutic potential of these compounds in muscle disease.
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Banco de datos:
MEDLINE
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
/
Dinoprostona
/
Estrés Oxidativo
/
Músculo Esquelético
/
Factor Neurotrófico Derivado del Encéfalo
/
Creatina Quinasa
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Neuromuscul Disord
Asunto de la revista:
NEUROLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Canadá