p53 germline polymorphisms are associated with an increased risk for breast cancer in German women.
Anticancer Res
; 18(3B): 2095-9, 1998.
Article
en En
| MEDLINE
| ID: mdl-9677474
ABSTRACT
Three germline p53 polymorphisms, a 16 bp duplication in intron 3, a Bst UI RFLP in exon 4 and Msp I RFLP in intron 6 have previously been tested for a association with Swedish breast cancer patients. The rare Bst UI allele was found to be associated with breast cancer in the Swedish patients (OR 1.47, 95% CI, 1.08-2.00). In our hospital-based case-control study leukocyte DNA of 107 breast cancer patients and 305 control women was analyzed. Individuals heterozygous at all 3 polymorphic sites (27/107) were over-represented in the breast cancer group with an age-adjusted OR of 2.01 (95% CI, 1.02-3.94). Haplotype analysis identified the 16 bp A2 allele (with 16 bp duplication) and Msp I A1 allele (loss of Msp I restriction site) as risk alleles. The results of this study suggest that the rare alleles 16 bp A 2 and Msp I A1 of the p53 locus may modify the risk of breast cancer in German women.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Genes p53
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Anticancer Res
Año:
1998
Tipo del documento:
Article
País de afiliación:
Alemania