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First phylogenetic analysis of Malian SARS-CoV-2 sequences provide molecular insights into the genomic diversity of the Sahel region
Bourema Kouriba; Angela Duerr; Alexandra Rehn; Abdoul Karim Sangare; Brehima Youssouf Traoure; Malena S Bestehorn-Willmann; Judicael LJ Ouedraogo; Asli Heitzer; Elisabeth Sogodogo; Abderrhamane Maiga; Mathias C Walter; Fee Zimmermann; Roman Woelfel; Markus H Antwerpen.
Afiliación
  • Bourema Kouriba; Centre d'Infectiologie Charles Merieux du Mali, Bamako, Mali
  • Angela Duerr; Bundeswehr Institute of Microbiology, Munich, Germany
  • Alexandra Rehn; Bundeswehr Institute of Microbiology, Munich, Germany
  • Abdoul Karim Sangare; Centre d'Infectiologie Charles Merieux du Mali, Bamako, Mali
  • Brehima Youssouf Traoure; Centre d'Infectiologie Charles Merieux du Mali, Bamako, Mali
  • Malena S Bestehorn-Willmann; Bundeswehr Institute of Microbiology, Munich, Germany
  • Judicael LJ Ouedraogo; Centre d'Infectiologie Charles Merieux du Mali, Bamako, Mali
  • Asli Heitzer; Bundeswehr Institute of Microbiology, Munich, Germany
  • Elisabeth Sogodogo; Centre d'Infectiologie Charles Merieux du Mali, Bamako, Mali
  • Abderrhamane Maiga; Centre d'Infectiologie Charles Merieux du Mali, Bamako, Mali
  • Mathias C Walter; Bundeswehr Institute of Microbiology, Munich, Germany
  • Fee Zimmermann; Bundeswehr Institute of Microbiology, Munich, Germany
  • Roman Woelfel; Bundeswehr Institute of Microbiology, Munich, Germany
  • Markus H Antwerpen; Bundeswehr Institute of Microbiology, Munich, Germany
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20165639
Artículo de revista
Un artículo publicado en revista científica está disponible y probablemente es basado en este preprint, por medio del reconocimiento de similitud realizado por una máquina. La confirmación humana aún está pendiente.
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ABSTRACT
We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occuring in the Wuhan region, China, in December 2019. From China the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on the 2nd of March 2020. Since whole genome sequencing (WGS) data is very crucial to understand the spreading dynamics of the ongoing pandemic, but only limited sequence data is available from the Sahel region to date, we have focused our efforts on generating the first Malian sequencing data available. Screening of 217 Malian patient samples for the presence of SARS-CoV-2 resulted in 38 positive isolates from which 21 whole genome sequences were generated. Our analysis shows that both, the early A (19B) and the fast evolving B (20A/C) clade, are present in Mali indicating multiple and independent introductions of the SARS-CoV-2 to the Sahel region.
Licencia
cc_by_nc_nd
Texto completo: 1 Banco de datos: PREPRINT-MEDRXIV Idioma: En Año: 2020 Tipo del documento: Preprint
Texto completo: 1 Banco de datos: PREPRINT-MEDRXIV Idioma: En Año: 2020 Tipo del documento: Preprint