Digoxin alleviates pulmonary fibrosis by inhibiting macrophage M2 polarization via regulating mTORC2-IRF4 signaling pathway

Miao YANG; Xiao-Feng MEI; Li-Dan JIA; Xin-Rong TIAN; Miao-Miao YAN; Xue MEI; Peng ZHAO; Xue-Fang LIU; Miao YANG; Xiao-Feng MEI; Li-Dan JIA; Xin-Rong TIAN; Miao-Miao YAN; Xue MEI; Peng ZHAO; Xue-Fang LIU; Peng ZHAO; Xue-Fang LIU

Digoxin alleviates pulmonary fibrosis by inhibiting macrophage M2 polarization via regulating mTORC2-IRF4 signaling pathway / 中国药理学通报

Miao YANG; Xiao-Feng MEI; Li-Dan JIA; Xin-Rong TIAN; Miao-Miao YAN; Xue MEI; Peng ZHAO; Xue-Fang LIU; Miao YANG; Xiao-Feng MEI; Li-Dan JIA; Xin-Rong TIAN; Miao-Miao YAN; Xue MEI; Peng ZHAO; Xue-Fang LIU; Peng ZHAO; Xue-Fang LIU.

Chinese Pharmacological Bulletin ; (12): 707-715, 2023.

Article en Zh | WPRIM | ID: wpr-1013927

Biblioteca responsable: WPRO

ABSTRACT

ABSTRACT

Aim To investigate the protective effect of digoxin (Dig) on the bleomycin (BLM)-induced pulmonary fibrosis in mice and the underlying mechanism. Methods Pulmonary fibrosis model was established by intratracheal instillation of BLM (5 mg · kg

Palabras clave

digoxin; IRF4; M2 polarization; macrophages; mTORC2; pulmonary fibrosis

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Texto completo: 1 Banco de datos: WPRIM Idioma: Zh Revista: Chinese Pharmacological Bulletin Año: 2023 Tipo del documento: Article

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Texto completo: 1 Banco de datos: WPRIM Idioma: Zh Revista: Chinese Pharmacological Bulletin Año: 2023 Tipo del documento: Article