Progress in targeted research of forkhead box protein O3a in degenerative disease / 实用医学杂志

ABSTRACT

Neurodegenerative diseases are irreversible neurological disorders caused by the loss or progres-sion lesion of specific neuronal cell populations in the brain or spinal cord.Neuroinflammation,oxidative stress,mitochondrial dysfunction,excitotoxicity,and protein may aggregation contribute to neurodegenerative processes.FoxO3a,an important member of the FoxO subfamily of Forkhead transcription factors,plays a crucial role in cell proliferation,apoptosis,autophagy and ROS detoxification through phosphorylation,ubiquitination mediated degra-dation,microsignal transduction and related protein pathways,which is closely related to the occurrence and devel-opment of neurodegenerative diseases.This article focuses on the mechanism of FoxO3a in neurodegenerative diseases and the targeting of related pathways in recent years were described,indicating that FoxO3a plays a key role in the occurrence and development of the disease,aiming to provide new research ideas for the prevention and treatment of this disease.