Endothelial Progenitor Cells' Classification and Application in Neurological Diseases
Tissue Engineering and Regenerative Medicine
; (6): 327-332, 2017.
Article
en En
| WPRIM
| ID: wpr-655428
Biblioteca responsable:
WPRO
ABSTRACT
The therapeutic effects of endothelial progenitor cells (EPCs) on ischemic stroke have been extensively studied in recent years. However, the differences in early EPCs and endothelial outgrowth cells (EOCs) are still unclear. Clarifications of their respective properties and specific functioning characteristics contribute to better applications of EPCs in ischemic diseases. In this review, we discuss cellular origin, isolation, culture, surface markers of early EPCs and EOCs and relevant applications in neurological diseases. We conclude that EOCs possess all haracteristics of true endothelial progenitors and have potent advantages in EPC-based therapies for ischemic diseases. A number of preclinical and clinical applications of EPCs in neurological diseases are under study. More studies are needed to determine the specific characteristics of EPCs and the relevant mechanisms of EPCs for neurological diseases.
Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Clasificación
/
Accidente Cerebrovascular
/
Usos Terapéuticos
/
Células Progenitoras Endoteliales
Idioma:
En
Revista:
Tissue Engineering and Regenerative Medicine
Año:
2017
Tipo del documento:
Article