Factors that Predict Clinical Benefit of EGFR TKI Therapy in Patients with EGFR Wild-Type Lung Adenocarcinoma / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 62-70, 2019.
Article
en En
| WPRIM
| ID: wpr-719616
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND:
Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancers have emerged as key predictive biomarkers in EGFR tyrosine kinase inhibitor (TKI) treatment. However, a few patients with wild-type EGFR also respond to EGFR TKIs. This study investigated the factors predicting successful EGFR TKI treatment in lung adenocarcinoma patients with wild-type EGFR.METHODS:
We examined 66 patients diagnosed with lung adenocarcinoma carrying wide-type EGFR who were treated with EGFR TKIs. The EGFR gene copy number was assessed by silver in situ hybridization (SISH). We evaluated the clinical factors and EGFR gene copy numbers that are associated with a favorable clinical response to EGFR TKIs.RESULTS:
The objective response rate was 12.1%, while the disease control rate was 40.9%. EGFR SISH analysis was feasible in 23 cases. Twelve patients tested EGFR SISH-positive, and 11 were EGFR SISH-negative, with no significant difference in tumor response and survival between EGFR SISH-positive and -negative patients. The overall median progression-free survival (PFS) and overall survival (OS) of 66 patients were 2.1 months and 9.7 months, respectively. Female sex and Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0–1 were independent predictors of PFS. ECOG PS 0–1 and a low tumor burden of extrathoracic metastasis were independent predictors of good OS.CONCLUSION:
Factors such as good PS, female sex, and low tumor burden may predict favorable outcomes following EGFR TKI therapy in patients with EGFR wild-type lung adenocarcinoma. However, EGFR gene copy number was not predictive of survival.Palabras clave
Texto completo:
1
Banco de datos:
WPRIM
Asunto principal:
Plata
/
Proteínas Tirosina Quinasas
/
Biomarcadores
/
Adenocarcinoma
/
Hibridación in Situ
/
Genes erbB-1
/
Supervivencia sin Enfermedad
/
Carga Tumoral
/
Receptores ErbB
/
Pulmón
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Tuberculosis and Respiratory Diseases
Año:
2019
Tipo del documento:
Article