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1.

The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5.

Polat, Onur K; Isaeva, Elena; Sudhini, Yashwanth R; Knott, Brenna; Zhu, Ke; Noben, Manuel; Suresh Kumar, Varsha; Endlich, Nicole; Mangos, Steve; Reddy, Tejasree Vallapu; Samelko, Beata; Wei, Changli; Altintas, Mehmet M; Dryer, Stuart E; Sever, Sanja; Staruschenko, Alexander; Reiser, Jochen.

Kidney Int ; 103(6): 1056-1062, 2023 06.

Article in English | MEDLINE | ID: mdl-36750145

2.

Soluble Urokinase Receptor and Acute Kidney Injury.

Hayek, Salim S; Leaf, David E; Samman Tahhan, Ayman; Raad, Mohamad; Sharma, Shreyak; Waikar, Sushrut S; Sever, Sanja; Camacho, Alex; Wang, Xuexiang; Dande, Ranadheer R; Ibrahim, Nasrien E; Baron, Rebecca M; Altintas, Mehmet M; Wei, Changli; Sheikh-Hamad, David; Pan, Jenny S-C; Holliday, Michael W; Januzzi, James L; Weisbord, Steven D; Quyyumi, Arshed A; Reiser, Jochen.

N Engl J Med ; 382(5): 416-426, 2020 01 30.

Article in English | MEDLINE | ID: mdl-31995687

3.

Renal cell markers: lighthouses for managing renal diseases.

Agarwal, Shivangi; Sudhini, Yashwanth R; Polat, Onur K; Reiser, Jochen; Altintas, Mehmet M.

Am J Physiol Renal Physiol ; 321(6): F715-F739, 2021 12 01.

Article in English | MEDLINE | ID: mdl-34632812

4.

Podocytes: Way to Go.

Altintas, Mehmet M; Reiser, Jochen.

Am J Pathol ; 189(2): 226-228, 2019 02.

Article in English | MEDLINE | ID: mdl-30543788

5.

More expression, less function: cleaved dynamin in glomerular kidney disease.

Altintas, Mehmet M; Reiser, Jochen.

J Pathol ; 247(4): 413-415, 2019 Apr.

Article in English | MEDLINE | ID: mdl-30549263

6.

TRPC5 Does Not Cause or Aggravate Glomerular Disease.

Wang, Xuexiang; Dande, Ranadheer R; Yu, Hao; Samelko, Beata; Miller, Rachel E; Altintas, Mehmet M; Reiser, Jochen.

J Am Soc Nephrol ; 29(2): 409-415, 2018 02.

Article in English | MEDLINE | ID: mdl-29061651

7.

Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1.

Lee, Ha Won; Khan, Samia Q; Khaliqdina, Shehryar; Altintas, Mehmet M; Grahammer, Florian; Zhao, Jimmy L; Koh, Kwi Hye; Tardi, Nicholas J; Faridi, Mohd Hafeez; Geraghty, Terese; Cimbaluk, David J; Susztak, Katalin; Moita, Luis F; Baltimore, David; Tharaux, Pierre-Louis; Huber, Tobias B; Kretzler, Matthias; Bitzer, Markus; Reiser, Jochen; Gupta, Vineet.

J Biol Chem ; 292(2): 732-747, 2017 Jan 13.

Article in English | MEDLINE | ID: mdl-27913625

8.

High-content screening assay-based discovery of paullones as novel podocyte-protective agents.

Lee, Ha Won; Arif, Ehtesham; Altintas, Mehmet M; Quick, Kevin; Maheshwari, Shrey; Plezia, Alexandra; Mahmood, Aqsa; Reiser, Jochen; Nihalani, Deepak; Gupta, Vineet.

Am J Physiol Renal Physiol ; 314(2): F280-F292, 2018 02 01.

Article in English | MEDLINE | ID: mdl-29046299

9.

Podocytes exhibit a specialized protein quality control employing derlin-2 in kidney disease.

Ren, Guohui; Tardi, Nicholas J; Matsuda, Fumihiko; Koh, Kwi Hye; Ruiz, Phillip; Wei, Changli; Altintas, Mehmet M; Ploegh, Hidde; Reiser, Jochen.

Am J Physiol Renal Physiol ; 314(3): F471-F482, 2018 03 01.

Article in English | MEDLINE | ID: mdl-29167172

10.

Single-nephron proteomes connect morphology and function in proteinuric kidney disease.

Höhne, Martin; Frese, Christian K; Grahammer, Florian; Dafinger, Claudia; Ciarimboli, Giuliano; Butt, Linus; Binz, Julia; Hackl, Matthias J; Rahmatollahi, Mahdieh; Kann, Martin; Schneider, Simon; Altintas, Mehmet M; Schermer, Bernhard; Reinheckel, Thomas; Göbel, Heike; Reiser, Jochen; Huber, Tobias B; Kramann, Rafael; Seeger-Nukpezah, Tamina; Liebau, Max C; Beck, Bodo B; Benzing, Thomas; Beyer, Andreas; Rinschen, Markus M.

Kidney Int ; 93(6): 1308-1319, 2018 06.

Article in English | MEDLINE | ID: mdl-29530281

11.

Soluble Urokinase Receptor and Chronic Kidney Disease.

Hayek, Salim S; Sever, Sanja; Ko, Yi-An; Trachtman, Howard; Awad, Mosaab; Wadhwani, Shikha; Altintas, Mehmet M; Wei, Changli; Hotton, Anna L; French, Audrey L; Sperling, Laurence S; Lerakis, Stamatios; Quyyumi, Arshed A; Reiser, Jochen.

N Engl J Med ; 373(20): 1916-25, 2015 Nov 12.

Article in English | MEDLINE | ID: mdl-26539835

12.

A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.

Lee, Ha Won; Khan, Samia Q; Faridi, Mohd Hafeez; Wei, Changli; Tardi, Nicholas J; Altintas, Mehmet M; Elshabrawy, Hatem A; Mangos, Steve; Quick, Kevin L; Sever, Sanja; Reiser, Jochen; Gupta, Vineet.

J Am Soc Nephrol ; 26(11): 2741-52, 2015 Nov.

Article in English | MEDLINE | ID: mdl-25858967

13.

Reduction of proteinuria through podocyte alkalinization.

Altintas, Mehmet M; Moriwaki, Kumiko; Wei, Changli; Möller, Clemens C; Flesche, Jan; Li, Jing; Yaddanapudi, Suma; Faridi, Mohd Hafeez; Gödel, Markus; Huber, Tobias B; Preston, Richard A; Jiang, Jean X; Kerjaschki, Dontscho; Sever, Sanja; Reiser, Jochen.

J Biol Chem ; 289(25): 17454-67, 2014 Jun 20.

Article in English | MEDLINE | ID: mdl-24817115

14.

Structure of the kidney slit diaphragm adapter protein CD2-associated protein as determined with electron microscopy.

Adair, Brian D; Altintas, Mehmet M; Möller, Clemens C; Arnaout, M Amin; Reiser, Jochen.

J Am Soc Nephrol ; 25(7): 1465-73, 2014 Jul.

Article in English | MEDLINE | ID: mdl-24511139

15.

Role of podocyte B7-1 in diabetic nephropathy.

Fiorina, Paolo; Vergani, Andrea; Bassi, Roberto; Niewczas, Monika A; Altintas, Mehmet M; Pezzolesi, Marcus G; D'Addio, Francesca; Chin, Melissa; Tezza, Sara; Ben Nasr, Moufida; Mattinzoli, Deborah; Ikehata, Masami; Corradi, Domenico; Schumacher, Valerie; Buvall, Lisa; Yu, Chih-Chuan; Chang, Jer-Ming; La Rosa, Stefano; Finzi, Giovanna; Solini, Anna; Vincenti, Flavio; Rastaldi, Maria Pia; Reiser, Jochen; Krolewski, Andrzej S; Mundel, Peter H; Sayegh, Mohamed H.

J Am Soc Nephrol ; 25(7): 1415-29, 2014 Jul.

Article in English | MEDLINE | ID: mdl-24676639

16.

Transient receptor potential channel 6 (TRPC6) protects podocytes during complement-mediated glomerular disease.

Kistler, Andreas D; Singh, Geetika; Altintas, Mehmet M; Yu, Hao; Fernandez, Isabel C; Gu, Changkyu; Wilson, Cory; Srivastava, Sandeep Kumar; Dietrich, Alexander; Walz, Katherina; Kerjaschki, Dontscho; Ruiz, Phillip; Dryer, Stuart; Sever, Sanja; Dinda, Amit K; Faul, Christian; Reiser, Jochen.

J Biol Chem ; 288(51): 36598-609, 2013 Dec 20.

Article in English | MEDLINE | ID: mdl-24194522

17.

Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.

Faridi, Mohd Hafeez; Altintas, Mehmet M; Gomez, Camilo; Duque, Juan Camilo; Vazquez-Padron, Roberto I; Gupta, Vineet.

Biochim Biophys Acta ; 1830(6): 3696-710, 2013 Jun.

Article in English | MEDLINE | ID: mdl-23454649

18.

TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function.

Reiser, Jochen; Polu, Krishna R; Möller, Clemens C; Kenlan, Peter; Altintas, Mehmet M; Wei, Changli; Faul, Christian; Herbert, Stephanie; Villegas, Ivan; Avila-Casado, Carmen; McGee, Mary; Sugimoto, Hikaru; Brown, Dennis; Kalluri, Raghu; Mundel, Peter; Smith, Paula L; Clapham, David E; Pollak, Martin R.

Nat Genet ; 37(7): 739-44, 2005 Jul.

Article in English | MEDLINE | ID: mdl-15924139

19.

The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease.

Zhu, Ke; Mukherjee, Kamalika; Wei, Changli; Hayek, Salim S; Collins, Agnieszka; Gu, Changkyu; Corapi, Kristin; Altintas, Mehmet M; Wang, Yong; Waikar, Sushrut S; Bianco, Antonio C; Koch, Alexander; Tacke, Frank; Reiser, Jochen; Sever, Sanja.

Sci Transl Med ; 15(714): eabq6492, 2023 09 20.

Article in English | MEDLINE | ID: mdl-37729431

20.

Podocyte GTPases regulate kidney filter dynamics.

Kistler, Andreas D; Altintas, Mehmet M; Reiser, Jochen.

Kidney Int ; 81(11): 1053-5, 2012 Jun.

Article in English | MEDLINE | ID: mdl-22584591

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